BREAST CANCER STAGE III

This study tests a combination of chemotherapy (Taxotere) and a targeted drug (trastuzumab) given before surgery to shrink tumors in Nigerian women with HER2-positive breast cancer. The main goal is to see how many women have no cancer cells left in the breast or lymph nodes at t…

This study looks at whether a combination of a targeted drug (palbociclib) and standard hormone therapy can work as well as chemotherapy for older patients with a common type of early breast cancer. The goal is to prevent the cancer from coming back while avoiding the harsh side …

This study looks at whether a 16-week exercise program can reduce inflammation in fat tissue for women who have finished treatment for early-stage breast cancer. About 100 participants will take part to see if movement helps lower markers linked to cancer recurrence. The goal is …

This study tests a technique called axillary reverse mapping (ARM) during breast cancer surgery to see if it can prevent lymphedema, a painful and chronic arm swelling. About 534 women with early-stage breast cancer will be followed for 3 years. The goal is to find out if mapping…

This early-stage study tests an experimental drug called BL-M17D1 in 120 adults with advanced solid tumors that have a specific protein (HER2) or a HER2 gene change. The main goals are to check the drug's safety, find the right dose, and see if it shrinks tumors. Participants mus…

This study tests whether the DigniCap scalp cooling system can prevent chemotherapy-induced hair loss in Black patients with early-stage breast cancer. About 30 participants will use the cooling cap during at least four cycles of taxane or anthracycline-based chemo. The goal is t…

This study tests two different vaccines in people who had HER-2 positive breast cancer and still had cancer cells after initial treatment. The goal is to see if the vaccines are safe and can help prevent the cancer from coming back. Participants receive a series of vaccine shots …

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The program is designed with community input t…

This study looks at whether a cardiopulmonary exercise test (CPET) can help predict heart and lung function in women with HER2-positive breast cancer who have mild heart problems from their treatment. About 23 women will do a special exercise test to measure oxygen use. The goal …

This study looks at whether a special decision aid helps people with early-stage breast cancer feel more confident and involved when choosing their surgery. It includes over 600 patients, focusing on those with fewer resources. The goal is to see if the tool boosts patient engage…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …

This study looks at 100 people with stage II or III breast cancer who are already getting radiation. It compares proton beam radiation to standard X-ray radiation to see which one causes less damage to the heart and lungs. The goal is to learn which type of radiation is safer, no…