BRAIN METASTASASES

This study tests a new way to deliver radiation to large brain tumors. Instead of the usual 5 daily treatments on one machine, patients get 4 treatments on one machine, a break, then a final treatment on a different, more precise machine. The goal is to improve tumor control and …

This early-phase study is testing a combination of two drugs, alpelisib and pembrolizumab, in people with metastatic breast cancer or melanoma that has spread to the brain. The main goal is to find a safe dose and check for side effects. About 50 adults whose cancer has not respo…

This early-phase trial tests an investigational drug (GSK5764227) that targets a protein called B7-H3 found on some brain tumor cells. It will enroll 15 people with recurrent grade 4 glioma or brain metastases from other cancers. The study first measures how much drug reaches the…

This study compares bevacizumab, a drug that blocks blood vessel growth, to standard steroid treatment for people with brain damage from radiation therapy. About 408 adults with brain tumors or high-grade glioma who develop symptomatic radiation necrosis will be randomly assigned…

This study looks at whether a sample of spinal fluid can find cancer DNA in people whose solid tumors have spread to the brain or its lining. Researchers will compare results from 60 participants with different types of brain involvement. The goal is to see if this liquid biopsy …