ANEURYSMAL SUBARACHNOID HEMORRHAGE

This study tests whether the drug deferiprone can safely lower iron levels in the brain after a bleeding aneurysm. About 66 adults who had a ruptured aneurysm will receive either deferiprone or a placebo for 14 days. Researchers will measure iron in spinal fluid, brain MRI scans,…

This study tests whether a steroid pill called fludrocortisone can reduce death and disability in people who have had a brain bleed from a burst aneurysm. The trial will enroll 524 critically ill adults who have had their aneurysm secured. Half will receive the drug, half a place…

This study looks at a new way to treat severe brain bleeds caused by aneurysms. Instead of coiling the whole aneurysm, doctors will only coil the dome (the bulging part). The goal is to see if this lowers the risk of re-bleeding and improves recovery. The study will enroll 30 adu…

This study tests whether starting lumbar drainage and injecting the clot-busting drug urokinase early after a severe brain bleed improves patients' recovery. About 424 adults with a first-time severe aneurysmal subarachnoid hemorrhage will be randomly assigned to get either the a…

This study tests whether injecting the blood pressure drug nicardipine into the spinal fluid can improve recovery in people who develop blood vessel spasms after a brain aneurysm rupture. About 396 adults who have had aneurysm repair and a drain placed will receive either the dru…

This study is testing a device called NeVa VS that helps open narrowed brain arteries in people who have had a certain type of stroke (aneurysmal subarachnoid hemorrhage). The device is already approved for emergency use. Researchers will watch 200 adults to see how well the devi…

This study tests a drug called deferoxamine in people who have had a severe type of stroke caused by a burst brain aneurysm. The drug works by removing extra iron that can damage the brain after the bleeding. Researchers want to see if it helps patients recover better over six mo…

This study tests a drug called tocilizumab-aazg in 30 adults who have had a burst brain aneurysm. The goal is to see if the drug is safe and might help prevent strokes that can happen after the bleeding. Participants will receive the drug within 24 hours of the aneurysm rupture a…

This study aims to develop a machine learning system that can detect delayed cerebral ischemia (a lack of blood flow to the brain) early in patients who have had a stroke. Researchers will analyze heart rate, brain waves, and specific proteins in blood and spinal fluid from 1,500…

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study is looking at 2,000 people who have had a type of stroke called an aneurysmal subarachnoid hemorrhage (a brain bleed). Researchers will collect blood, spinal fluid, urine, and stool samples to study the body's molecules (genes, proteins, etc.). The goal is to find clue…

This study is looking at 160 people who had a ruptured brain aneurysm and need a temporary drain. Researchers will measure glucose in their spinal fluid and blood daily for up to 14 days. The goal is to see if higher glucose levels are linked to needing a permanent shunt later. P…

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real life, not just in controlled trials. No new treatments are being tested—just data gathe…

This study is collecting health data from 5,000 people who have had a brain bleed from a ruptured aneurysm. Researchers aim to find factors that predict complications, disability, or death. They will use this information to build computer models that could help doctors make more …

This study looks at whether levels of nitric oxide in spinal fluid can predict dangerous blood vessel spasms after a type of brain bleed called subarachnoid hemorrhage. Researchers will compare nitric oxide levels in 40 patients with and without this condition. The goal is to fin…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…