ANAPLASTIC ASTROCYTOMA

This study tests whether taking two targeted pills (dabrafenib and trametinib) after radiation therapy can help children and young adults up to age 25 with a specific type of aggressive brain cancer (BRAF V600-mutant high-grade glioma). The drugs block proteins that fuel tumor gr…

This study aimed to test whether adding a special virus (Toca 511) and a fungus-fighting drug (Toca FC) to standard chemotherapy and radiation could help people with newly diagnosed glioblastoma, an aggressive brain cancer. The virus was designed to make cancer cells convert the …

This study tests a cancer vaccine called SurVaxM in 35 children whose brain tumors have come back or are hard to treat. The vaccine teaches the immune system to find and destroy tumor cells. The goal is to see if it is safe and helps control the disease.

This study tests whether adding the drug veliparib to standard radiation and chemotherapy can help children and young adults with a newly diagnosed aggressive brain tumor called high-grade glioma. Veliparib blocks a protein that helps cancer cells repair themselves, potentially m…

This study tests whether doing extra MRI scans each week during radiation treatment can help doctors adjust the radiation plan to better target high-grade gliomas, a type of aggressive brain tumor. About 20 adults with newly diagnosed tumors will receive standard radiation plus w…

This study compares proton beam therapy to standard photon radiation (IMRT) in 120 people with IDH-mutant grade II or III gliomas. The goal is to see which method better preserves memory and thinking skills after treatment. Both techniques aim to deliver radiation precisely to th…

This study is observing 1000 adults with recurrent malignant gliomas (aggressive brain tumors) to see how they respond to chemotherapy and targeted therapy. Researchers are tracking survival and tumor progression over time. The goal is to gather real-world data to guide future tr…