AML
Clinical trials for AML explained in plain language.
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Can a Chemo-Transplant combo rescue patients whose leukemia resists standard treatment?
Cure CompletedThis trial tests a treatment strategy for adults with acute myeloid leukemia (AML) that did not respond to standard induction chemotherapy. Participants receive clofarabine and intermediate-dose Ara-C chemotherapy, followed by a reduced-intensity allogeneic stem cell transplant u…
Matched conditions: AML
Phase 2 • Sponsor: Nantes University Hospital • Aim: Cure
Last updated Sep 16, 2026 00:00 UTC
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Gentler transplant prep aims to cure tough blood cancers
Cure CompletedResearchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…
Matched conditions: AML
Phase 2 • Sponsor: Nantes University Hospital • Aim: Cure
Last updated Sep 16, 2026 00:00 UTC
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Personalized leukemia vaccine aims to outsmart relapse
Cure CompletedThis study tests a personalized vaccine made from a patient's own leukemia cells fused with immune cells, combined with a drug that blocks PD-1, to help the immune system recognize and destroy any remaining leukemia cells after chemotherapy. The goal is to prevent the cancer from…
Matched conditions: AML
Phase 2 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Cure
Last updated Jul 16, 2026 00:00 UTC
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Can a liposomal chemo combo improve outcomes before stem cell transplant?
Disease control CompletedResearchers are testing whether a liposomal chemotherapy drug called CPX-351 works better than standard chemotherapy before an allogeneic stem cell transplant in adults with higher-risk myelodysplastic syndromes (MDS) or oligoblastic acute myeloid leukemia (AML). The trial enroll…
Matched conditions: AML
Phase 2 • Sponsor: GWT-TUD GmbH • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Could lenalidomide boost chemo for tough AML?
Disease control CompletedThis phase 2 trial tested whether adding lenalidomide to standard MEC chemotherapy helps adults with relapsed or refractory acute myeloid leukemia (AML) achieve remission. 41 participants received the combination. The main goal was to see how many achieved complete remission. Thi…
Matched conditions: AML
Phase 2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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First step for new AML drug: safety check in healthy volunteers
Knowledge-focused CompletedThis study tested a new drug called ZE46-0134 in 112 healthy adults to see if it is safe and how the body handles it. The drug is being developed for a type of blood cancer called AML. Since this was the first time the drug was given to people, the main goal was to check for side…
Matched conditions: AML
Phase 1 • Sponsor: Lomond Therapeutics Holdings, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC