ALZHEIMERS DISEASE

This study tests whether a surgical procedure that connects lymph vessels in the neck to veins can help people with moderate-to-severe Alzheimer's disease. The surgery is designed to improve the brain's waste-clearing system. 376 participants will be randomly assigned to receive …

This study tests a nasal spray called Foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray is designed to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and be follo…

This study tests an experimental drug called trontinemab in 800 people with early Alzheimer's (mild memory problems to mild dementia). The goal is to see if it can slow down worsening of memory and daily living skills over 72 weeks. Participants receive either the drug or a place…

This study tests an experimental drug called trontinemab in 800 people with early Alzheimer's (mild memory problems to mild dementia). The goal is to see if it can slow down the disease over 72 weeks compared to a placebo. Participants will have regular memory tests, brain scans,…

This study tests whether investigational drugs can prevent or slow the buildup of harmful proteins in the brain that lead to Alzheimer's. It involves 280 adults who carry a gene mutation that almost guarantees they will develop the disease. The goal is to see if early treatment c…

This study tests a drug called remternetug in 280 people who have a genetic mutation that almost always causes Alzheimer's disease. The goal is to see if the drug can prevent or slow down early brain changes before memory problems begin. Participants will receive either the drug …

This study aims to scientifically prove whether music therapy has a real effect on Alzheimer's disease. Researchers will measure brain-related molecules (like serotonin and amyloid-beta) in the saliva of 60 older adults—some healthy, some with mild memory problems, and some with …

This study is a large pre-screening effort to identify people who may be eligible for future Alzheimer's drug trials. It will enroll up to 13,000 adults with recent memory concerns, measuring a key blood biomarker (pTau217) and cognitive performance. The goal is to efficiently ma…

This study looks at how people with mild cognitive impairment (MCI) or Alzheimer's disease adjust their walking to changes in their environment. Researchers will test 10 older adults using special treadmills and walking tasks to measure how well they adapt their steps. The goal i…