Yolk sac tumor
MONDO:0005744A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.
Also known as: endodermal sinus neoplasm, endodermal sinus tumor, hepatoid yolk sac tumor, yolk SAC tumor, malignant, yolk Sac neoplasm, yolk Sac tumor, yolk Sac tumor site unspecified, yolk Sac tumour site unspecified
2751 clinical trials for this condition and its sub-types, 12 tagged with Yolk sac tumor itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Yolk sac tumor
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Ovarian yolk sac tumor 1 trial
4 sub-types
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Testicular yolk sac tumor 1 trial
10 sub-types
- Enteric pattern testicular yolk sac tumor 0 trials
- Polyvesicular vitelline pattern testicular yolk sac tumor 0 trials
- Reticular pattern testicular yolk sac tumor 0 trials
- Testicular yolk sac tumor, endodermal sinus pattern 0 trials
- Testicular yolk sac tumor, glandular-alveolar pattern 0 trials
- Testicular yolk sac tumor, hepatoid pattern 0 trials
- Testicular yolk sac tumor, macrocystic pattern 0 trials
- Testicular yolk sac tumor, myxomatous pattern 0 trials
- Testicular yolk sac tumor, papillary pattern 0 trials
- Testicular yolk sac tumor, solid pattern 0 trials
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Childhood endodermal sinus tumor 0 trials · 1 incl. sub-types
2 sub-types
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Childhood ovarian yolk sac tumor 0 trials
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Yolk sac tumor of central nervous system 0 trials · 1 incl. sub-types
1 sub-type
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
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Adult yolk sac tumor 0 trials
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Mediastinal yolk sac tumor 0 trials
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Vaginal yolk sac tumor 0 trials
Most studied deeper sub-types
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High-Dose chemo with stem cell transplant tested against standard therapy for tough germ cell cancers
Disease control OngoingThis phase 3 trial compares two chemotherapy approaches for people with germ cell tumors that have returned or not responded to initial treatment. One group receives standard-dose chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP). The other receives high-dose chemothe…
Phase 3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Supercharged immune cells take on tough cancers in early human test
Disease control OngoingThis early-phase trial tests a new experimental treatment called CATCH T cells in up to 12 adults with certain solid tumors (like liver cancer or Wilms tumor) that have returned or not responded to standard care. The cells are the patient's own T cells, genetically modified in th…
Phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Supercharged t cells take on childhood cancers
Disease control OngoingThis early-phase trial tests a new immunotherapy called AGAR T cells in children with solid tumors such as liver cancer, Wilms tumor, and rhabdomyosarcoma that have returned or not responded to standard care. The cells are made from the patient's own T cells, which are geneticall…
Phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC