Viral respiratory tract infection

This study tested a nasal spray RSV vaccine in nearly 1,000 healthy infants and toddlers aged 6 to 22 months. The goal was to see if a lower dose works as well as the standard dose and to check safety across different doses. The trial was ended early, so final results are not ava…

This early-stage trial tests an experimental RSV vaccine called CodaVax-RSV, given as nose drops, in healthy children aged 6 months to 5 years. The study evaluates the vaccine's safety and the immune response it triggers. Some children receive the vaccine at different doses, whil…

This study tested an experimental RSV vaccine given to healthy infants at 6 and 12 months old alongside their regular vaccines. The goal was to see if the RSV vaccine still worked well when given at the same time. About 2,200 babies took part, but the study was stopped early.

This phase 3 study tested an intranasal RSV vaccine in about 6,300 healthy children aged 6 to 22 months. The goal was to see if two doses of the nasal spray could prevent lower respiratory tract infections caused by RSV. The trial was terminated early, so final results are not av…

This study tests an inhaled medicine called SNG001 in patients with severe viral pneumonia who need a breathing machine. The goal is to see if it safely helps clear the virus faster and lowers the risk of death. About 550 adults, mostly over 50 or with weakened immune systems, wi…

This phase 2 study tests whether an oral antiviral pill called obeldesivir can safely shorten RSV symptoms in adults who are not hospitalized but are at higher risk for severe disease (e.g., those aged 60+ or with chronic lung conditions). Participants take the pill or a placebo,…

This early-phase trial tested a new therapy called CYNK-001, which uses natural killer cells from the placenta to fight COVID-19. It enrolled only 7 adults with moderate COVID-19. The study was terminated early, so we have limited information on safety and effectiveness.

This study tests an oral drug called AK0529 (Ziresovir) in adults aged 18 to 75 with respiratory syncytial virus (RSV) infection. Participants receive either the drug or a placebo, and researchers measure how well symptoms improve and track any side effects. The goal is to see if…

This study tested whether breathing in nitric oxide gas could keep mild-to-moderate COVID-19 from becoming severe. Researchers enrolled 62 hospitalized adults who were breathing on their own. The goal was to see if the gas reduced the need for a breathing tube. The trial was stop…

This Phase 2 trial tested the drug silmitasertib (CX-4945) plus standard care in adults with pneumonia caused by COVID-19 or influenza. The goal was to see if the drug could reduce the need for hospitalization or prevent death. The study planned to enroll 120 people but was termi…

This study tested the safety and dosing of sisunatovir, an experimental antiviral drug, in infants and children up to 5 years old with RSV lower respiratory tract infection. Ten participants received either the drug or a placebo. The goal was to find the right dose for future stu…

This study tested an oral drug called sisunatovir for treating RSV in adults who were not hospitalized but had a high risk of severe illness. Participants took either the drug or a placebo for 5 days. The study was terminated early, so results are limited.

This early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…

This trial tests whether sending caregivers text messages with digital stories can encourage them to vaccinate their young children against the flu. The study focuses on Black children aged 6 months to 5 years who receive care at Denver Health, a group that has faced long-standin…

This trial tests whether giving older adults a high dose of vitamin D before their flu shot can strengthen their immune response. Participants are 65 or older with low vitamin D levels. The study measures changes in infection-fighting proteins and antibody levels after vaccinatio…

This study tested whether a high-dose flu vaccine works better than the standard dose in preventing the flu in children aged 6 to 35 months. About 100 children took part, receiving either the high-dose or standard-dose shot. The study was stopped early, so results are limited.

This study compared a high-dose flu vaccine to the standard-dose shot in over 33,000 adults aged 65 and older. The goal was to see if the high-dose version could better prevent hospitalizations for heart and lung problems. The trial was terminated early, so the full picture is no…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study compared a newer recombinant flu vaccine (RIV4, also called Supemtek or Flublok Quadrivalent) to the standard egg-based flu vaccine in 366 children aged 3 to 8 years. The goal was to see if the recombinant vaccine produced a similar immune response and was as safe. The…

This study tested an oral antiviral drug called obeldesivir in children from birth to under 5 years old who had RSV infection. The goal was to see if the drug is safe and helps reduce symptoms faster. However, the trial was stopped early and only enrolled 4 participants, so the r…

Researchers are studying adults with COPD who go to the emergency room or day hospital for sudden worsening of their breathing. The study checks how many of these patients test positive for respiratory syncytial virus (RSV) during the RSV season, from October to April. They compa…

Researchers are studying how a person's age, first flu exposure, and vaccination history affect the immune system's response to the seasonal flu shot. Healthy adults and children aged 9 and older receive a standard quadrivalent flu vaccine, with blood samples taken before and aft…

This study aimed to compare how the immune system responds to two different seasonal flu vaccines given at the same time. Healthy adults aged 18-49 who had not received a flu shot in at least three years were eligible. The study was terminated early and only enrolled 2 participan…