Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome

This study tests the drug acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. Researchers want to see if acalabrutinib causes fewer heart-related side effects compared to other standard treatments. About 60 adults will t…

This early study tests a new device that uses a special wire with radiofrequency energy to safely cross the wall between the heart's upper chambers. This step is needed for procedures that treat heart rhythm problems or close the left atrial appendage. The study will enroll 60 ad…

This study tests a new device called the CellFX nsPFA catheter, which uses short electrical pulses instead of heat to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if it is safe and effective at restoring normal rhythm in 215 adults who …

This study tests a new device called the CellFX Nano-PFA 360 catheter, which uses very short electrical pulses to treat atrial fibrillation (an irregular heartbeat). About 60 adults aged 18 to 75 with paroxysmal atrial fibrillation will receive this procedure. The goal is to see …

This study tests a single, precise dose of radiation to the heart to treat dangerous arrhythmias in 60 patients who haven't improved with medication or standard procedures. Researchers will monitor changes in heart rhythm events and medication use over 18 months. The goal is to s…

This study compares two procedures for treating persistent atrial fibrillation (AF): catheter ablation (which scars tiny areas in the heart to block faulty signals) and DC cardioversion (an electric shock to restore normal rhythm). Researchers want to see which one better prevent…

This study tests whether a chest-strap ECG wearable, the Frontier X Plus, can accurately detect heart rhythm problems compared to the standard MoMe ARC patch monitor. About 15 active adults who are already prescribed a heart monitor will wear both devices at the same time. Resear…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study compares a new wearable armband called HeartWatch to the standard Holter monitor for detecting heart rhythm problems like atrial fibrillation. About 300 adults who need a Holter test will wear both devices at the same time. The goal is to see if the HeartWatch can accu…

This study tests whether a sedative called dexmedetomidine can help people in the ICU who have a life-threatening heart rhythm problem called electrical storm. About 192 adults will receive either the sedative or a placebo for 2-3 days. The goal is to see if it reduces deaths and…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…

This study is observing 4,500 people who need pacemakers or similar heart devices. The goal is to create a tool that predicts who is at risk of developing a weakened heart from the device itself. By identifying high-risk patients early, doctors can choose better pacing methods to…

Researchers at the Heart Center Bad Berka run a registry that collects data on adults treated for heart rhythm problems. The registry follows people who receive medication, procedures such as ablation, or implanted cardiac devices. It tracks how safe and effective these treatment…

This study is collecting information from 280 people who need a heart rhythm procedure using BIOTRONIK catheters, external devices, or sheaths. The goal is to track how well the devices work and any problems that may happen during or shortly after the procedure. It is a routine s…

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study looks at whether certain medications known to affect the heart's electrical activity (QT-prolonging drugs) actually cause major heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients across Ontario hospitals, comparing those who…