Urea cycle disorder
MONDO:0004739A genetic inborn error of metabolism characterized by the deficiency of one of the enzymes necessary for the urea cycle. It results in accumulation of ammonia in the body.
Also known as: disorder of urea cycle metabolism, inborn disorder of urea cycle metabolism and ammonia detoxification, inborn urea cycle disorder, urea cycle disorders, urea cycle metabolism disorder, UCD, disorder of urea cycle metabolism and ammonia detoxification
30 clinical trials for this condition and its sub-types, 14 tagged with Urea cycle disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Urea cycle disorder
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Urea cycle disorder or inherited hyperammonemia 0 trials · 24 incl. sub-types
10 sub-types
- Ornithine carbamoyltransferase deficiency 16 trials
- Arginase deficiency 8 trials
- Argininosuccinic aciduria 4 trials
- Carbamoyl phosphate synthetase I deficiency disease 4 trials
- Citrullinemia type I 4 trials Sub-types →
- Citrin deficiency 3 trials Sub-types →
- Ornithine translocase deficiency 3 trials
- Hyperammonemia due to N-acetylglutamate synthase deficiency 2 trials
- Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency 1 trial
- Hyperinsulinism-hyperammonemia syndrome 1 trial
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Citrullinemia 2 trials · 6 incl. sub-types
2 sub-types
- Citrullinemia type I 4 trials Sub-types →
- Citrin deficiency 3 trials Sub-types →
Most studied deeper sub-types
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Can a new injection tame the toxic ammonia of urea cycle disorders?
Disease control Not yet recruitingThis early-stage trial is evaluating an experimental drug called KRRO-121, given as a shot under the skin, to see if it is safe and tolerable. The study first tests KRRO-121 in healthy adults, then in people with urea cycle disorders—a group of inherited conditions that impair th…
Phase 1/2 • Sponsor: Korro Bio, Inc. • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Robotic surgery breakthrough aims to slash chest pain after esophageal cancer surgery
Symptom relief Not yet recruitingThis early-stage trial tests a new robotic surgical method for esophageal cancer that avoids cuts between the ribs, which may cause less chest pain and faster recovery. About 31 adults with stage I to III esophageal cancer will be randomly assigned to either the new approach or s…
Phase 1 • Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Could a breath test replace blood draws for metabolic disease monitoring?
Knowledge-focused Not yet recruitingThis study measures specific substances (metabolites) in the breath and blood of people with inherited metabolic disorders, those on a special ketogenic diet for epilepsy, and healthy volunteers. The goal is to see if a simple breath test can reliably track these metabolites, pot…
Sponsor: University Children's Hospital, Zurich • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Diabetic eye patients at risk for extra retinal scarring?
Knowledge-focused Not yet recruitingThis study will look at 225 adults with diabetic retinopathy to find out how many also develop an epiretinal membrane — a thin, scar-like layer on the retina that can blur vision. Researchers will use eye scans to detect the membrane and check for related factors like age, diabet…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC