Tonsillar squamous cell carcinoma

MONDO:0006470

A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass.

Also known as: SCC of the tonsil, SCC of tonsil, palatine tonsil squamous cell carcinoma, squamous cell carcinoma of the tonsil, squamous cell carcinoma of tonsil, tonsil SCC, tonsil squamous cell carcinoma, tonsillar SCC

2962 clinical trials for this condition and its sub-types, 4 tagged with Tonsillar squamous cell carcinoma itself.

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Where it sits in the disease tree

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Part of

↑ Oropharynx squamous cell carcinoma (195) ↑ Tonsil carcinoma (5)

Including sub-types (2962) Tagged with Tonsillar squamous cell carcinoma (4)

Trials to join now! 3 Terminated 1

Promising combo for HPV throat cancer hits snag: trial stopped early

Disease control Stopped early

This study looked at adding two immunotherapy drugs (ipilimumab and nivolumab) to standard radiation for people with advanced HPV-positive throat cancer. The goal was to see if the combination was safe and could shrink tumors better than radiation alone. The trial enrolled 37 par…

Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control

Last updated Jun 27, 2026 12:26 UTC

Tonsillar squamous cell carcinoma

Where it sits in the disease tree

Promising combo for HPV throat cancer hits snag: trial stopped early