Tongue squamous cell carcinoma
MONDO:0000500A squamous cell carcinoma that arises from the tongue. It usually presents as a painful ulcerated or nodular lesion. The size of the tumor and the status of the lymph nodes are the most important factors that determine prognosis.
Also known as: scc of the tongue, scc of tongue, squamous cell carcinoma of the tongue, squamous cell carcinoma of tongue, tongue scc, tongue squamous cell carcinoma
2974 clinical trials for this condition and its sub-types, 9 tagged with Tongue squamous cell carcinoma itself.
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Browse by category →Sub-types of Tongue squamous cell carcinoma
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New drug EVOLVE104 takes on tough cancers in early human trial
Disease control Recruiting nowThis early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…
Phase 1 • Sponsor: EvolveImmune United, Inc • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Less neck surgery may spare shoulder function in oral cancer patients
Disease control Recruiting nowThis study tests whether a less invasive surgery called sentinel lymph node biopsy can replace standard neck dissection for early-stage oral cavity cancer. About 686 patients will be randomly assigned to one of the two procedures. The goal is to see if the gentler approach mainta…
Phase 2/3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Can early speech therapy help cancer patients swallow and speak better after surgery?
Symptom relief Recruiting nowThis study looks at whether starting speech and swallowing therapy early — before and just after surgery — can help people with head and neck cancer recover better. Forty patients will either get early therapy sessions with a speech-language pathologist or the usual care. The mai…
Sponsor: University Health Network, Toronto • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Smart probe could help surgeons remove all cancer in one go
Knowledge-focused Recruiting nowThis study tests a device called SpiderMass that analyzes tissue molecules in real time during tongue cancer surgery. The goal is to help surgeons instantly tell cancerous from healthy tissue, so they can remove all the tumor in one operation. Currently, about 15-30% of patients …
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC