Thrombophilia
MONDO:0002305A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome.
Also known as: excessive blood clotting, hypercoagulability, hypercoagulability state, hypercoagulable
78 clinical trials for this condition and its sub-types, 12 tagged with Thrombophilia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Thrombophilia
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Inherited thrombophilia 0 trials · 28 incl. sub-types
12 sub-types
- Thrombophilia due to thrombin defect 19 trials
- Thrombophilia due to activated protein C resistance 5 trials
- Hereditary antithrombin deficiency 3 trials
- Hereditary thrombophilia due to congenital protein C deficiency 1 trial Sub-types →
- Factor 5 excess with spontaneous thrombosis 0 trials
- Heparin cofactor 2 deficiency 0 trials
- Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency 0 trials
- Hereditary thrombophilia due to congenital protein S deficiency 0 trials Sub-types →
- Thrombomodulin-related bleeding disorder 0 trials
- Thrombophilia, X-linked, due to factor 8 defect 0 trials
- Thrombophilia, X-linked, due to factor 9 defect 0 trials
- Thrombophilia, familial, due to decreased release of tissue plasminogen activator 0 trials
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Thrombotic thrombocytopenic purpura 15 trials · 20 incl. sub-types
2 sub-types
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Disseminated intravascular coagulation 15 trials
2 sub-types
- Disseminated intravascular coagulation in newborn 0 trials
- Purpura fulminans 0 trials Sub-types →
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Protein S deficiency 3 trials
1 sub-type
Most studied deeper sub-types
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New fingerstick test for blood thinner monitoring put to the test
Diagnosis CompletedThis study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…
Sponsor: LumiraDx UK Limited • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Shorter blood thinner course after delivery may be safe for some women
Prevention CompletedThis study looked at 86 women with Factor V Leiden or Factor II mutations who had no history of blood clots. Researchers compared how long doctors prescribed blood thinners after childbirth (less than 2 weeks vs. 6 weeks) to see if shorter treatment was still effective at prevent…
Sponsor: Hospices Civils de Lyon • Aim: Prevention
Last updated Jun 27, 2026 12:04 UTC
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Scientists hunt for clot clues in sickle cell blood
Knowledge-focused CompletedThis study examined blood samples from 119 adults with sickle cell disease, sickle cell trait, or no condition to understand why some develop dangerous blood clots. Participants gave blood and had health check-ins over two years. The goal was to find biomarkers that could lead to…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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New blood test benchmarks for pregnant women could prevent dangerous clots
Knowledge-focused CompletedThis study looked at 100 pregnant women to determine normal ranges for a blood test called dRVVT, which checks for clotting problems. The goal is to better identify antiphospholipid syndrome, a condition that raises the risk of blood clots and pregnancy complications. By establis…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Hidden danger: muscle disease linked to deadly clots
Knowledge-focused CompletedThis study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:53 UTC