Tenosynovial giant cell tumor
MONDO:0002522A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse.
Also known as: fibrous histiocytoma of tendon sheath, giant cell neoplasm of Tenosynovium, giant cell neoplasm of tendon sheath, giant cell neoplasm of the Tenosynovium, giant cell tumor of Tenosynovium, giant cell tumor of tendon sheath, giant cell tumor of the Tenosynovium, giant cell tumour of the Tenosynovium
1464 clinical trials for this condition and its sub-types, 12 tagged with Tenosynovial giant cell tumor itself.
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Sub-types of Tenosynovial giant cell tumor
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New pill shows promise for rare joint tumor in early trial
Disease control Recruiting nowThis phase 2 trial tests a daily oral drug called pimicotinib in 20 Japanese adults with tenosynovial giant cell tumor (TGCT) that cannot be removed by surgery. The study aims to see if the drug is safe, how it moves through the body, and whether it shrinks tumors. Participants t…
Phase 2 • Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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New pill for tough tumors enters human testing
Disease control Recruiting nowThis early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the best dose, while also seeing if the drug can shrink…
Phase 1 • Sponsor: Abbisko Therapeutics Co, Ltd • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Glow-in-the-Dark dye may help surgeons spot hidden tumor cells
Diagnosis Recruiting nowThis study tests whether a dye called indocyanine green (ICG) can help surgeons see tenosynovial giant cell tumors (TGCT) during surgery. About 40 people with TGCT will get an ICG injection before their operation. The dye makes tumor tissue glow under a special camera, which surg…
Phase 4 • Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC
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New study tracks how TGCT patients fare on vimseltinib in everyday life
Knowledge-focused Recruiting nowThis observational study follows 100 people with tenosynovial giant cell tumor (TGCT) who are taking vimseltinib as part of their routine care. Researchers will collect data on how long patients stay on the drug and how it affects their quality of life. The study does not change …
Sponsor: Deciphera Pharmaceuticals, LLC • Aim: Knowledge-focused
Last updated Jul 29, 2026 00:00 UTC
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Liver risk under microscope: TURALIO study seeks answers
Knowledge-focused Recruiting nowThis study follows up to 30 adults with tenosynovial giant cell tumor (TGCT) who had liver test abnormalities while taking TURALIO. The goal is to track long-term liver failure risk and understand how the drug may cause liver injury. Participants will be monitored after stopping …
Sponsor: Daiichi Sankyo • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC