Telomere syndrome

This trial tests whether infusions of stem cells from human umbilical cords can help people with primary biliary cholangitis, a liver disease that damages bile ducts. It is for patients who have not responded well to the standard medicine, ursodeoxycholic acid. The study first ch…

This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway invo…

This study will follow 100 adults with primary biliary cirrhosis (PBC) who are taking seladelpar in Germany and Switzerland. Researchers will collect real-world data to see if the drug helps improve liver function tests after 48 weeks. The goal is to understand how well seladelpa…

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This Phase 2a trial tests TH104, a nalmefene strip placed inside the cheek, for moderate to severe itching in primary biliary cholangitis (PBC). About 40 adults with PBC will receive either TH104 or a placebo to see if it safely reduces itch. The study is not yet recruiting.

This study looks at people with primary biliary cholangitis (PBC), a chronic liver disease that can lead to cirrhosis and liver failure. Researchers will review medical records from hundreds of patients to identify risk factors for faster disease progression. The goal is to build…

This French study will collect medical data and biological samples from 800 people with autoimmune liver diseases. Researchers hope to identify new markers that explain why some patients respond well to treatment while others do not. The goal is to better understand the immune me…

This study looks at whether measuring spleen stiffness with a simple ultrasound-like test (FibroScan) can help doctors better predict complications in people with Primary Biliary Cholangitis (PBC). Researchers will follow 125 adults already on standard treatment, adding a spleen …