T-cell large granular lymphocyte leukemia
MONDO:0019469T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage.
Also known as: LGLL, T gamma lymphoproliferative disorder, T-LGL, T-LGL leukaemia, T-LGL leukemia, T-cell LGL leukaemia, T-cell LGL leukemia, T-cell large gran. lymph. leuk.
1968 clinical trials for this condition and its sub-types, 18 tagged with T-cell large granular lymphocyte leukemia itself.
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New pill combo takes on Hard-to-Treat cancers
Disease control OngoingThis early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …
Phase 1 • Sponsor: Pfizer • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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New hope for rare bone marrow diseases: drug tames immune attack
Disease control OngoingThis study tests a pill called ruxolitinib for people whose immune system attacks their bone marrow, causing conditions like severe anemia. The drug aims to stop this attack and help the bone marrow recover. Participants take the pill twice daily for up to 6 months and are follow…
Phase 1/2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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New pill shows promise for Hard-to-Treat blood cancer
Disease control OngoingThis early-phase trial is testing an oral chemotherapy drug called azacitidine (CC-486) in 11 adults with a rare type of leukemia (T-LGLL) that has come back or not responded to prior treatment. The study aims to find the best dose and see how well the drug works at shrinking or …
Phase 1/2 • Sponsor: Jonathan Brammer • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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New strategy aims to tame common virus after stem cell transplants
Disease control OngoingThis study tests a modified plan to prevent and treat cytomegalovirus (CMV) infection in people with blood cancers who have had a donor stem cell transplant. CMV is a common virus that can cause serious problems after transplant. The study involves 153 participants and looks at w…
Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Scientists unravel genetic secrets of bone marrow failure
Knowledge-focused By invitation onlyThis study aims to understand the genetic and molecular changes in people with bone marrow failure disorders. Researchers will analyze blood and bone marrow samples from up to 1,400 participants to track how these changes evolve over time. The goal is to better predict disease ou…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC