T-B+ severe combined immunodeficiency due to gamma chain deficiency

MONDO:0010315

Severe combined immunodeficiency (SCID) due to gamma chain deficiency, also called SCID-X1, is a form of SCID characterized by severe and recurrent infections, associated with diarrhea and failure to thrive.

Also known as: SCIDX1, T-B+ SCID due to gamma chain deficiency, T-B+ severe combined immunodeficiency due to gamma chain deficiency, T-B+ severe combined immunodeficiency, X-linked, X-linked severe combined immunodeficiency, XSCID, severe combined immunodeficiency, X-linked, X-linked recessive, SCID, X-linked

12 clinical trials for this condition and its sub-types, 10 tagged with T-B+ severe combined immunodeficiency due to gamma chain deficiency itself.

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Where it sits in the disease tree

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↑ Familial severe combined immunodeficiency (22) ↑ T-B+ severe combined immunodeficiency (10)

Including sub-types (12) Tagged with T-B+ severe combined immunodeficiency due to gamma chain deficiency (10)

Trials to join now! 3 Not yet recruiting 1 Not yet finished but already full! 4 Completed 2

Bubble boy disease gene therapy trial launches

Disease control Not yet recruiting

This trial tests a gene therapy given by IV for X-linked severe combined immunodeficiency (SCID-X1), a rare immune disorder. Ten participants with no matched donor will receive a lentiviral vector to correct the genetic defect. The goal is to restore immune function and improve s…

Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control

Last updated Aug 29, 2026 00:00 UTC

T-B+ severe combined immunodeficiency due to gamma chain deficiency

Where it sits in the disease tree

Bubble boy disease gene therapy trial launches