Syphilis
MONDO:0005976A contagious bacterial infection caused by the spirochete Treponema pallidum. It is a sexually transmitted disorder, although it can also be transmitted from the mother to the fetus in utero. Typically, it is initially manifested with a single sore which heals without treatment. If the infection is left untreated, the initial stage is followed by skin rash and mucous membrane lesions. A late stage follows, which is characterized by damage of the internal organs, including the nervous system.
Also known as: Treponema pallidum caused disease or disorder, Treponema pallidum disease or disorder, Treponema pallidum infectious disease
65 clinical trials for this condition and its sub-types, 47 tagged with Syphilis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Syphilis
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Congenital syphilis 7 trials
2 sub-types
- Early congenital syphilis 0 trials
- Late congenital syphilis 0 trials
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Primary syphilis 7 trials
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Yaws 3 trials · 4 incl. sub-types
4 sub-types
- Early yaws 1 trial
- Late yaws 0 trials
- Latent yaws 0 trials
- Tertiary lesion of yaws 0 trials
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Latent syphilis 1 trial · 2 incl. sub-types
2 sub-types
- Latent early syphilis 2 trials
- Late latent syphilis 0 trials
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Tertiary syphilis 0 trials · 2 incl. sub-types
4 sub-types
- Neurosyphilis 0 trials · 2 incl. sub-types Sub-types →
- Cardiovascular syphilis 0 trials
- Gummatous syphilis 0 trials
- Late latent syphilis 0 trials
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Secondary syphilis 1 trial
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Bejel 0 trials
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Chancre 0 trials
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Cutaneous syphilis 0 trials
1 sub-type
- Late yaws 0 trials
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Syphilitic aortitis 0 trials
Most studied deeper sub-types
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One-Stop clinic aims to cut infections in veterans with opioid disorder
Disease control Not yet recruitingThis study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Can 'Queen Mothers' bring HIV testing to the doorstep?
Diagnosis Not yet recruitingResearchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …
Sponsor: University of North Carolina, Chapel Hill • Aim: Diagnosis
Last updated Sep 20, 2026 00:00 UTC
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One fingerstick, three infections: new rapid test under study
Diagnosis Not yet recruitingThis study will test a new rapid device called TruPlex that checks for HIV, Hepatitis B, and Syphilis using a single fingerstick blood sample. About 500 adults at risk for these infections will take part. Researchers want to see if the test is accurate and easy for trained staff …
Sponsor: bioLytical Laboratories • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Quick ER test could spot HIV and syphilis in pregnant women, saving babies
Diagnosis Not yet recruitingThis study will test a rapid fingerstick test for HIV and syphilis in pregnant women who come to the emergency department without prior prenatal care. Researchers want to see if offering this test leads to more women being diagnosed and starting treatment right away. The goal is …
Sponsor: The University of Texas Health Science Center, Houston • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC
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New All-in-One test could save thousands of babies from infections
Diagnosis Not yet recruitingThis study will check if a new device called MagIA H3S can accurately detect HIV, hepatitis B, hepatitis C, and syphilis in pregnant women in the Democratic Republic of the Congo. About 7,500 pregnant women will take part. The goal is to see if this quick test works as well as st…
Sponsor: Gardiens de Vies • Aim: Diagnosis
Last updated Jun 27, 2026 09:02 UTC
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New 10-Minute syphilis test could save mothers and babies in uganda
Diagnosis Not yet recruitingSyphilis affects about 1 in 25 pregnant women in Uganda and can harm both mother and baby if untreated. This study will test a new rapid test that gives results in 10 minutes, comparing it to standard lab tests that take hours or days. Researchers will enroll 24 mothers and their…
Sponsor: St George's, University of London • Aim: Diagnosis
Last updated Jun 26, 2026 17:22 UTC
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Could a single pill after sex stop STIs in women?
Prevention Not yet recruitingThis trial tests whether taking a single dose of the antibiotic doxycycline within 24 hours of condomless sex can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in women aged 18–35 at increased risk. Participants are randomly assi…
Phase 4 • Sponsor: Tulane University • Aim: Prevention
Last updated Jul 17, 2026 00:00 UTC
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Home test kits could transform STI screening for sex workers
Knowledge-focused Not yet recruitingThis study explores whether providing home self-sampling kits for six sexually transmitted infections (STIs) can help sex workers get tested more easily. Participants receive a kit to collect samples at home and return them by mail, along with a questionnaire about their backgrou…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Free sexual health Check-Ups: will they satisfy young people?
Knowledge-focused Not yet recruitingThis study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…
Sponsor: University of Zurich • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC