Steroid-resistant nephrotic syndrome
MONDO:0044765Nephrotic syndrome, occurring in the pediatric population, in which proteinuria does not normalize with administration of steroids; this condition is unresponsive to a minimum of four weeks administration of oral corticosteroids.
Also known as: nephrotic syndrome of childhood - steroid resistant, nephrotic syndrome-steroid-resistant, steroid-resistant nephrotic syndrome, nephrotic syndrome, idiopathic, steroid-resistant, nephrotic syndrome, steroid-resistant, autosomal recessive, NPHS2, SRNS - steroid-resistant nephrotic syndrome, steroid-unresponsive nephrotic syndrome
17 clinical trials for this condition and its sub-types, 5 tagged with Steroid-resistant nephrotic syndrome itself.
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Sub-types of Steroid-resistant nephrotic syndrome
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Nephrotic syndrome 14 3 trials
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Sporadic idiopathic steroid-resistant nephrotic syndrome 0 trials · 2 incl. sub-types
3 sub-types
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14 sub-types
- Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 0 trials
- Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 0 trials
- Familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 0 trials
- Familial steroid-resistant nephrotic syndrome with sensorineural deafness 0 trials
- Focal segmental glomerulosclerosis 1 0 trials
- Nephrotic syndrome, type 10 0 trials
- Nephrotic syndrome, type 11 0 trials
- Nephrotic syndrome, type 12 0 trials
- Nephrotic syndrome, type 13 0 trials
- Nephrotic syndrome, type 2 0 trials
- Nephrotic syndrome, type 3 0 trials
- Nephrotic syndrome, type 6 0 trials
- Nephrotic syndrome, type 8 0 trials
- Nephrotic syndrome, type 9 0 trials
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CAR-T therapy aimed at tough kidney disease in kids — but trial never started
Disease control CancelledThis was a planned early-stage trial to test whether anti-CD19 CAR-T cells could safely help children with multi-drug resistant nephrotic syndrome, a serious kidney condition. The study was withdrawn before any patients were enrolled, so no data on safety or effectiveness were co…
Phase 1 • Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for kids with tough kidney disease: obinutuzumab may replace steroids
Disease control OngoingThis study tests a new drug called obinutuzumab in 100 children aged 1-18 with refractory nephrotic syndrome, a kidney condition causing swelling and protein loss. The drug targets immune cells to reduce disease flares and dependence on steroids and other medications. Researchers…
Sponsor: Children's Hospital of Chongqing Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC