Solitary osseous plasmacytoma

MONDO:0002755

A localized, clonal (malignant) plasma cell infiltrate in the bone, without peripheral blood involvement. The most commonly affected bones are the vertebrae, ribs, skull, pelvis and femur. X-rays examination reveals a solitary lytic lesion.

Also known as: isolated plasmacytoma of bone, solitary plasmacytoma of bone, SPB

1926 clinical trials for this condition and its sub-types, 4 tagged with Solitary osseous plasmacytoma itself.

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Where it sits in the disease tree

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↑ Plasmacytoma (17)

Including sub-types (1926) Tagged with Solitary osseous plasmacytoma (4)

Trials to join now! 1 Not yet finished but already full! 2 Terminated 1

New combo therapy aims to stop rare bone cancer from spreading

Disease control Recruiting now

This phase 2 trial tests whether combining radiation with a bispecific antibody called CM336 can safely treat solitary bone plasmacytoma, a rare plasma cell tumor that often turns into multiple myeloma. The study will enroll 21 adults with mild bone marrow involvement. Researcher…

Phase 2 • Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Disease control

Last updated Jun 26, 2026 14:59 UTC

Solitary osseous plasmacytoma

Where it sits in the disease tree

New combo therapy aims to stop rare bone cancer from spreading