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New combo therapy aims to stop rare bone cancer from spreading

NCT ID NCT07115667

Disease control Sponsor: Institute of Hematology & Blood Diseases Hospital, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tests whether combining radiation with a bispecific antibody called CM336 can safely treat solitary bone plasmacytoma, a rare plasma cell tumor that often turns into multiple myeloma. The study will enroll 21 adults with mild bone marrow involvement. Researchers will monitor side effects, especially immune overreactions, and track how long participants stay cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BCMA/CD3 bispecific antibody (CM336) combined with radiation therapy
What this could lead to
If successful, this combination could offer a new treatment option that delays or prevents progression to multiple myeloma for people with solitary bone plasmacytoma.
What could go wrong
This is a small, early-phase trial with only 21 participants, so results may not apply broadly. The bispecific antibody can cause serious side effects like cytokine release syndrome (CRS) and nerve toxicity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 78 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years old * Histologically confirmed SBP with \<10% clonal plasma cells in marrow * ECOG ≤ 2 * No prior anti-myeloma therapy. Previous local radiotherapy for SBP is not an exclusion criterion. * Meets laboratory and imaging criteria Exclusion Criteria: 1. Patients who have previously received anti-plasma cell therapy, including melphalan, cyclophosphamide, proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, bispecific antibodies, or chimeric antigen receptor T-cell (CAR-T) therapy. 2. Any condition that, in the opinion of the investigator, would make the patient unsuitable for participation in this study.

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Conditions

The condition(s) this trial relates to.

plasma cell neoplasm primary plasmacytoma of the bone solitary osseous plasmacytoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Plasma cell disorders Plasmacytoma of bone Solitary bone plasmacytoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

    RECRUITING

    Tianjin, 300020, China

More trials for these conditions

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