Small intestinal bacterial overgrowth
MONDO:0400000The presence of excessive bacteria in the small intestine that can result from result from failure of the gastric acid barrier, failure of small intestinal motility, anatomic alterations, or impairment of systemic and local immunity.
Also known as: SIBO
24 clinical trials for this condition and its sub-types, 18 tagged with Small intestinal bacterial overgrowth itself.
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Could a probiotic yeast rival antibiotics for gut bloating and diarrhea?
Disease control Not yet recruitingResearchers are testing whether a probiotic yeast, Saccharomyces boulardii, works as well as the antibiotic rifaximin for adults with small intestinal bacterial overgrowth (SIBO) who have bloating and diarrhea. The trial enrolls 222 people aged 18 to 70 with a positive breath tes…
Phase 4 • Sponsor: Shandong University • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Herbal capsules take on gut bacteria: a new hope for IBS?
Disease control Not yet recruitingThis pilot study tests whether an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS). SIBO involves an overgrowth of bacteria in the small intestine, which can worsen IBS symptoms. About 40…
Phase 2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Could probiotics help antibiotics work better for gut bacteria overgrowth?
Disease control Not yet recruitingThis study looks at whether adding a specific probiotic (containing Enterococcus faecium and Bacillus subtilis) to the antibiotic rifaximin can improve treatment for small intestinal bacterial overgrowth (SIBO), a condition that causes bloating, pain, and diarrhea. About 100 adul…
Phase 4 • Sponsor: Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Could a Fiber-Rich diet beat constipation without pills?
Symptom relief Not yet recruitingThis study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …
Sponsor: Singapore Institute of Technology • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Hidden gut infection may explain why some pancreas patients stay sick
Knowledge-focused Not yet recruitingThis study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC