Severe pre-eclampsia
MONDO:0001641Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.
Also known as: Preeclampsia with severe features, severe preeclampsia
59 clinical trials for this condition and its sub-types, 27 tagged with Severe pre-eclampsia itself.
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Sub-types of Severe pre-eclampsia
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HELLP syndrome 13 trials
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Placental clues from a past pregnancy may guide treatment to prevent future complications
Disease control Recruiting nowThis pilot trial tests whether using placental tissue analysis from a prior complicated pregnancy can guide treatment with the blood thinner enoxaparin to reduce the risk of recurrent adverse outcomes. The study enrolls women who had a previous pregnancy affected by early deliver…
Phase 2 • Sponsor: Endeavor Health • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Could a mitochondrial antioxidant help manage preeclampsia?
Disease control Recruiting nowThis study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…
Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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Could a drug for rare blood disorder help pregnant women with severe preeclampsia?
Disease control Recruiting nowThis Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Could a daily baby aspirin help moms recover from severe preeclampsia?
Disease control Recruiting nowThis study is testing whether taking a low-dose aspirin (81 mg) daily for three weeks after giving birth can improve blood vessel function in women who had severe preeclampsia. About 100 women will be randomly assigned to receive either aspirin or a placebo. The main goal is to s…
Phase 2 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Ultrasound could prevent deadly lung complications in preeclampsia
Diagnosis Recruiting nowThis study tests whether lung ultrasound can detect fluid overload in women with severe preeclampsia, a condition that can lead to life-threatening pulmonary edema. Researchers will scan the lungs of 202 pregnant women at three key times: upon admission, right after delivery, and…
Sponsor: Saint Thomas Hospital, Panama • Aim: Diagnosis
Last updated Jun 27, 2026 08:01 UTC
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New combo therapy aims to prevent dangerous pregnancy condition
Prevention Recruiting nowThis study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…
Phase 4 • Sponsor: Alexandra Hospital, Athens, Greece • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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Scientists hunt for hidden culprit behind dangerous pregnancy condition
Knowledge-focused Recruiting nowThis study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…
Sponsor: University of Alabama at Birmingham • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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Egg donation pregnancy study seeks clues to dangerous blood pressure disorder
Knowledge-focused Recruiting nowThis study follows 462 women pregnant after egg donation or standard IVF to learn why pre-eclampsia is more common in egg donation pregnancies. Participants give blood samples and have regular check-ups throughout pregnancy. The goal is to find early warning signs and improve car…
Sponsor: Copenhagen University Hospital, Hvidovre • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Hidden breathing risk after c-section in severe preeclampsia: study aims to find out how common it is
Knowledge-focused Recruiting nowThis study looks at how often the diaphragm — the main muscle used for breathing — becomes weak after a C-section in women with severe preeclampsia. Researchers will use ultrasound to measure diaphragm movement before and 24 hours after surgery in 52 women. The goal is to find ou…
Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC