Severe hemophilia A
MONDO:0015719Severe hemophilia A is a form of hemophilia A characterized by a large deficiency of factor VIII leading to frequent spontaneous hemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction.
Also known as: severe factor VIII deficiency, severe haemophilia type A, severe hemophilia type A
63 clinical trials for this condition and its sub-types, 50 tagged with Severe hemophilia A itself.
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New hope for kids with hemophilia: altuviiio trial aims to tame inhibitors
Disease control Not yet recruitingThis phase 4 trial tests whether Altuviiio (efanesoctacog alpha) can help children with severe hemophilia A and high-titer inhibitors achieve immune tolerance. Participants also receive Hemlibra (emicizumab) to prevent bleeding. The study involves 15 children under 18 and will tr…
Phase 4 • Sponsor: Versiti Blood Health • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New study tracks safety of clotting drug for hemophilia patients in india
Disease control Not yet recruitingThis study looks at the safety and effectiveness of Octocog alfa, a lab-made clotting factor, when used to treat sudden bleeding episodes in adults with severe hemophilia A. About 33 people in India who have used factor VIII before will take part. Researchers will track side effe…
Sponsor: Bayer • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can a Once-Weekly shot cut the burden of hemophilia a?
Knowledge-focused Not yet recruitingResearchers are studying how switching to efanesoctocog alfa (ALTUVOCT), a long-acting factor VIII therapy given once a week, affects adults and children with severe or moderate hemophilia A in routine care. The study tracks factor use, treatment satisfaction, and quality of life…
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Sep 21, 2026 16:00 UTC
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Hemophilia a bone health under the microscope: which treatment wins?
Knowledge-focused Not yet recruitingThis study will follow 50 men with severe hemophilia A for five years to compare bone density between those taking emicizumab and those taking efanesoctocog alfa. Researchers will also measure bone remodeling markers and joint health. The goal is to see if one treatment is linked…
Sponsor: Arkansas Children's Hospital Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Growing up with hemophilia: new study tracks health habits from teen to adult
Knowledge-focused Not yet recruitingThis study follows 75 young adults with severe hemophilia who were part of an earlier study as teens. Researchers want to see if their healthcare habits change as they become adults and what factors help them stick to treatment. The goal is to understand how to support a smooth t…
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC