Secondary hemophagocytic lymphohistiocytosis

MONDO:0015542

Hemophagocytic lymphohistiocytosis due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.

Also known as: acquired hemophagocytic lymphohistiocytosis, acquired hemophagocytic syndrome, reactive hemophagocytic syndrome

24 clinical trials for this condition and its sub-types, 15 tagged with Secondary hemophagocytic lymphohistiocytosis itself.

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Where it sits in the disease tree

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↑ Hemophagocytic syndrome (58)

Sub-types of Secondary hemophagocytic lymphohistiocytosis

Macrophage activation syndrome 13 trials
Acquired hemophagocytic lymphohistiocytosis associated with malignant disease 2 trials

Including sub-types (24) Tagged with Secondary hemophagocytic lymphohistiocytosis (15)

Trials to join now! 11 Not yet recruiting 1 Not yet finished but already full! 6 Completed 6

New study aims to uncover hidden danger in kawasaki disease

Knowledge-focused Not yet recruiting

This study will observe 150 children with Kawasaki disease to learn more about a rare but serious complication called Macrophage Activation Syndrome (MAS). Researchers will collect data on symptoms, lab results, and treatments across multiple European hospitals. The goal is to be…

Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:00 UTC

Secondary hemophagocytic lymphohistiocytosis

Where it sits in the disease tree

New study aims to uncover hidden danger in kawasaki disease