Secondary hemophagocytic lymphohistiocytosis
MONDO:0015542Hemophagocytic lymphohistiocytosis due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.
Also known as: acquired hemophagocytic lymphohistiocytosis, acquired hemophagocytic syndrome, reactive hemophagocytic syndrome
24 clinical trials for this condition and its sub-types, 15 tagged with Secondary hemophagocytic lymphohistiocytosis itself.
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Sub-types of Secondary hemophagocytic lymphohistiocytosis
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Macrophage activation syndrome 13 trials
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Could a simple drug tame the dangerous side effects of CAR-T cancer therapy?
Disease control CancelledThis study tests whether giving the drug anakinra early can prevent severe cytokine release syndrome (CRS) in children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) who are receiving CAR-T cell therapy. Participants receive anakinra at the first sign of fever,…
Phase 1/2 • Sponsor: Kevin McNerney • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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Engineered t cells with a kill switch aim to make stem cell transplants safer
Disease control OngoingThis study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…
Phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Suicide Gene-Equipped t cells aim to make stem cell transplants safer
Disease control OngoingThis trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…
Phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC