Sea-blue histiocyte syndrome

MONDO:0010017

A rare, inherited or acquired syndrome characterized by the presence of histiocytes in the bone marrow which contain granules stained blue with hematoxylin-eosin stain, mild thrombocytopenia and purpura, and splenomegaly.

Also known as: SEA-blue histiocyte disease, histiocytosis, Sea-blue, inherited Lipemic splenomegaly, sea-blue histiocytosis

6 clinical trials for this condition and its sub-types, 0 tagged with Sea-blue histiocyte syndrome itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Sphingolipidosis (166) ↑ Syndromic dyslipidemia (73) ↑ Non-Langerhans cell histiocytosis (39)

Including sub-types (6) Tagged with Sea-blue histiocyte syndrome (0)

Trials to join now! 1 Not yet finished but already full! 4 Completed 1

New drug targets tough childhood cancers with genetic flaws

Disease control Completed

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jun 27, 2026 12:23 UTC

Sea-blue histiocyte syndrome

Where it sits in the disease tree

New drug targets tough childhood cancers with genetic flaws