Schizophreniform disorder

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests whether carefully reducing antipsychotic medication in stable schizophrenia patients can improve their daily functioning compared to staying on the same dose. Researchers will group 288 adults aged 18–60 by their specific psychosis type and randomly assign them t…

Researchers are testing two mobile app-based programs, CHAMPS and iCanChange, for young adults with first-episode psychosis who use cannabis. CHAMPS targets safer use for people not looking to quit, while iCanChange supports those who want to reduce or stop. The trial compares ea…

This study tests a 12-week online program designed to improve mood and motivation in people with schizophrenia or early psychosis. Participants complete 20-30 minute weekly sessions. Researchers will measure changes in symptoms and goal-directed behavior before and after the prog…

This study tests a new therapy that combines face-to-face sessions with virtual reality (VR) to help people with psychosis manage their emotions. Participants will practice emotion regulation skills in realistic VR scenarios with live coaching from a therapist. Fifteen people wit…

This study tests whether a 45-minute session of viewing visual illusions with a partner can improve social cognition in people with psychotic disorders. Social cognition is the ability to understand what others think or feel. Sixty participants will be guided through illusion box…

This study tests a smartphone app called NST-SPARK that uses augmented reality games to help people with schizophrenia who struggle with low motivation, lack of pleasure, and social withdrawal. About 30 adults with these symptoms will use the app for 12 weeks. The goal is to see …

This study tests a shared decision-making tool for antipsychotic medications in 120 young adults (ages 18-30) with early psychosis. The goal is to see if the tool helps patients feel more involved in their care and more likely to stick with treatment. Participants will use the de…

This study tests whether a type of talk therapy called narrative exposure therapy (NET) is practical and helpful for people with psychosis who have experienced trauma. One participant will receive NET sessions and complete questionnaires about their symptoms and experiences. The …

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

Researchers at King's College London are studying what happens in the brain when people hear voices or sounds others cannot hear, known as auditory hallucinations. The study compares people with schizophrenia, schizoaffective disorder, or related psychotic conditions to people wi…

This study uses PET scans to see how two antipsychotic medications, brexpiprazole and cariprazine, bind to dopamine-3 receptors in the brains of people with schizophrenia. Forty participants take one of the drugs for 15 days and get brain scans before, after one day, and after 15…

This study looks at how people with a first episode of psychosis tell their life stories and whether that relates to their well-being and recovery. Researchers will compare 96 participants—those with early psychosis, those with chronic psychosis, and healthy controls—using questi…

This study investigates how insulin delivered through the nose changes dopamine signaling and energy use in the brains of people with first-episode psychosis. Researchers will compare brain scans and chemical levels in 46 participants (patients and healthy volunteers) after recei…