Retinopathy of prematurity
MONDO:0006952A bilateral retinopathy characterized by neovascularization, scarring, retinal detachment, and eventually blindness. It may be mild or severe. It occurs in babies born prematurely. Causes include oxygen toxicity and hypoxia.
Also known as: ROP, Terry syndrome, retrolental fibroplasia
51 clinical trials for this condition and its sub-types, 33 tagged with Retinopathy of prematurity itself.
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Can a single eye injection save sight in premature infants?
Disease control CompletedThis trial investigates whether an injection of ranibizumab, a drug that blocks abnormal blood vessel growth, can effectively treat aggressive posterior retinopathy of prematurity (AP-ROP) in premature infants. AP-ROP is a fast-progressing eye condition that can lead to retinal d…
Sponsor: Ain Shams University • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Could a smartphone camera spot blinding eye diseases?
Diagnosis CompletedThis study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…
Sponsor: University of Michigan • Aim: Diagnosis
Last updated Aug 22, 2026 00:00 UTC
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Robot eye doctor could save Preemies' sight
Diagnosis CompletedThis study tested a computer system called i-ROP DL that automatically checks eye images from premature babies for a serious condition called retinopathy of prematurity (ROP), which can cause blindness. Researchers used over 1,200 babies' eye photos from multiple hospitals to see…
Sponsor: Siloam Vision • Aim: Diagnosis
Last updated Jun 27, 2026 08:05 UTC
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Can music soothe premature babies during painful eye exams?
Symptom relief CompletedThis trial tests whether playing different types of music during retinopathy of prematurity (ROP) eye exams can reduce pain and improve comfort in premature infants. ROP exams are necessary but can be painful and stressful for babies. Researchers will compare pain and comfort sco…
Sponsor: Necmettin Erbakan University • Aim: Symptom relief
Last updated Sep 06, 2026 00:00 UTC
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Can smarter screening save premature Babies' sight?
Knowledge-focused CompletedThis study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Could steroid eye drops save premature Babies' sight?
Knowledge-focused CompletedThis study tested dexamethasone eye drops in 11 premature infants at risk of blindness from retinopathy of prematurity. Researchers measured how the drug enters the blood and saliva, and monitored for side effects. The goal was to gather safety and dosing information, not to prov…
Phase 1 • Sponsor: Region Skane • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Could Omega-3 levels predict eye problems in preemies?
Knowledge-focused CompletedThis study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature newborns born before 29 weeks. The goal was to see if lower …
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Massive study of 7,000 preemies aims to save sight
Knowledge-focused CompletedThis completed study looked at over 7,000 premature infants to understand which babies develop a serious eye condition called retinopathy of prematurity (ROP) and need treatment. Researchers used a cloud-based database to compare risk factors and outcomes. The goal was to improve…
Sponsor: Alaska Blind Child Discovery • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Iron overload linked to blindness risk in preemies?
Knowledge-focused CompletedThis study looked at 175 premature babies to see if high iron levels in their blood during the first month of life are linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured iron-related markers and tracked which babies developed ROP. The …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Baby eye treatment checked years later: did it last?
Knowledge-focused CompletedThis study followed about 100 babies who were treated for retinopathy of prematurity (ROP) with either Eylea injections or laser therapy in an earlier trial. Researchers checked their vision and eye health years later to see how well the treatments held up. The goal is to underst…
Phase 3 • Sponsor: Bayer • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC