Restrictive cardiomyopathy
MONDO:0005201A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium.
Also known as: restrictive cardiomyopathy, familial restrictive cardiomyopathy
335 clinical trials for this condition and its sub-types, 18 tagged with Restrictive cardiomyopathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Restrictive cardiomyopathy
-
Non-familial restrictive cardiomyopathy 0 trials · 251 incl. sub-types
7 sub-types
- AL amyloidosis 92 trials · 98 incl. sub-types Sub-types →
- Wild type ATTR amyloidosis 95 trials
- Hypereosinophilic syndrome 19 trials · 49 incl. sub-types Sub-types →
- Cardiac sarcoidosis 19 trials
- AA amyloidosis 2 trials
- Loeffler endocarditis 0 trials
- Tropical endomyocardial fibrosis 0 trials
-
Familial restrictive cardiomyopathy 0 trials · 62 incl. sub-types
10 sub-types
- Glycogen storage disease II 31 trials · 41 incl. sub-types Sub-types →
- Gaucher disease type I 12 trials
- ATTRV122I amyloidosis 7 trials
- Atrial standstill 1 trial Sub-types →
- Idiopathic hypereosinophilic syndrome 1 trial Sub-types →
- Cardiomyopathy, familial restrictive, 1 0 trials
- Cardiomyopathy, familial restrictive, 2 0 trials
- Cardiomyopathy, familial restrictive, 3 0 trials
- Cardiomyopathy, familial restrictive, 6 0 trials
- Dilated cardiomyopathy 1KK 0 trials
-
Endomyocardial fibrosis 16 trials
Most studied deeper sub-types
-
Heart drug acoramidis tested for Long-Term cardiac repair in rare amyloidosis
Disease control Recruiting nowThis study tests the drug acoramidis in people with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart, weakening it. Over 36 months, researchers measure whether acoramidis improves heart function and structure using cardiac …
Phase 4 • Sponsor: Eidos Therapeutics, a BridgeBio company • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
-
Could a diabetes drug help hearts stiffened by amyloid?
Disease control Recruiting nowThis study tests whether Enavogliflozin, a drug used for diabetes, can help people with amyloid cardiomyopathy, a condition where abnormal proteins build up in the heart. About 68 adults with heart failure symptoms will take the drug or a placebo for 12 weeks, then switch. The ma…
Phase 4 • Sponsor: Seoul St. Mary's Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
-
Heart MRI upgrade could spot damage faster
Diagnosis Recruiting nowThis study tests new, faster MRI techniques to get detailed images of the heart muscle in people with heart conditions like cardiomyopathy, myocarditis, and ischemic heart disease. The goal is to improve diagnosis and treatment planning. About 240 adults who already need a heart …
Sponsor: Medical University of South Carolina • Aim: Diagnosis
Last updated Jun 27, 2026 07:56 UTC
-
New drug aims to stop rare genetic disease before it strikes
Prevention Recruiting nowThis phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …
Phase 3 • Sponsor: Eidos Therapeutics, a BridgeBio company • Aim: Prevention
Last updated Aug 06, 2026 00:00 UTC
-
Nationwide registry aims to crack the code of a rare protein-clogging disease
Knowledge-focused Recruiting nowThis study is a national registry in Hungary that collects medical information from people diagnosed with systemic amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will look at patient records to understand how the disease starts, how it is diag…
Sponsor: Semmelweis University • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
-
Gene hunt launched for kids with heart muscle disease
Knowledge-focused Recruiting nowThis study aims to uncover the genetic causes of cardiomyopathy in children by analyzing DNA from affected individuals and their families. Researchers hope to identify mutations that lead to different types of cardiomyopathy, which could improve genetic counseling and deepen unde…
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
-
Brazil launches massive heart gene hunt to unlock hereditary mysteries
Knowledge-focused Recruiting nowThis study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…
Sponsor: Hospital do Coracao • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
-
Heart MRI may unlock secrets of thick heart muscle diseases
Knowledge-focused Recruiting nowThis study uses advanced heart MRI scans to look at blood flow patterns in people with different types of hypertrophic cardiomyopathy (thick heart muscle), including rare forms like Anderson-Fabry disease and cardiac amyloidosis. Researchers will also study first-degree relatives…
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC