Respiratory distress syndrome in premature infants
MONDO:0009971Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.
Also known as: RDS, respiratory distress syndrome, RDS of prematurity, Respiratory Distress Syndrome, Infant, respiratory distress syndrome in premature infants, IRDS, NRDS, RDS - infants
178 clinical trials for this condition and its sub-types, 79 tagged with Respiratory distress syndrome in premature infants itself.
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Can gentle oscillations help premature babies breathe better?
Disease control CancelledThis trial tests whether adding gentle oscillations to standard nasal continuous positive airway pressure (NCPAP) improves breathing support for newborns with respiratory distress syndrome. Premature infants who need NCPAP will be randomly assigned to receive either oscillatory N…
Sponsor: University of Utah • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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New method aims to help premature babies breathe easier without a breathing tube
Disease control By invitation onlyThis study tests whether giving surfactant (a natural substance that helps lungs stay open) through a small airway device placed above the vocal cords, along with standard breathing support (CPAP), is better than CPAP alone for late preterm and early term infants with respiratory…
Sponsor: Sharp HealthCare • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New combo therapy aims to save tiny lungs
Disease control OngoingThis Phase 3 trial tests whether adding budesonide (an anti-inflammatory) to standard surfactant treatment helps extremely preterm babies avoid chronic lung disease or death. About 642 infants born before 29 weeks or weighing under 1000 grams will receive either the combo or surf…
Phase 3 • Sponsor: NICHD Neonatal Research Network • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Simple bedside ultrasound may spot lung risk in preemies
Knowledge-focused By invitation onlyThis study looks at whether a simple bedside lung ultrasound can predict chronic lung disease in premature infants born before 32 weeks. Researchers will perform ultrasounds on 150 babies with breathing problems and track their outcomes. The goal is to see if early ultrasound sco…
Sponsor: Phoenix Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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New Light-Based monitor could help protect newborn brains
Knowledge-focused OngoingThis study is observing brain oxygen levels in two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers use a non-invasive light sensor (near-infrared spectroscopy) to me…
Sponsor: University of Edinburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC