Recurrent respiratory papillomatosis
MONDO:0018955Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory infections, pneumonia, dysphagia, stridor, and/or failure to thrive.
Also known as: RRP, recurrent respiratory papillomatosis, AORRP (type), JORRP (type), adult-onset recurrent respiratory papillomatosis (type), juvenile laryngeal papilloma, juvenile-onset recurrent respiratory papillomatosis (type), laryngeal papilloma, recurrent
1442 clinical trials for this condition and its sub-types, 8 tagged with Recurrent respiratory papillomatosis itself.
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Sub-types of Recurrent respiratory papillomatosis
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Laryngeal papillomatosis 1 trial
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Experimental vaccine aims to tame rare throat tumor disease
Disease control Recruiting nowThis early-stage trial tests a custom-made vaccine for recurrent respiratory papillomatosis (RRP), a rare condition where non-cancerous growths keep coming back in the throat. The vaccine is made from each patient's own immune cells and designed to target the virus that causes RR…
Phase 1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New drug combo aims to reduce surgeries for rare HPV throat condition
Disease control Recruiting nowThis early-phase study tests two cancer drugs—lenvatinib (a daily pill) and pembrolizumab (an IV infusion)—in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink papillomas and reduce…
Phase 2 • Sponsor: Yale University • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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Gene therapy retreatment aims to cut surgeries for rare throat tumor condition
Disease control Recruiting nowThis study tests a gene therapy called Zopapogene imadenovec (Zopa) in 30 adults with recurrent respiratory papillomatosis (RRP), a condition causing non-cancerous throat tumors that often require repeated surgeries. One group will check how the virus used in the therapy leaves t…
Phase 4 • Sponsor: Precigen, Inc • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC