Pure autonomic failure
MONDO:0018608Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.
Also known as: Bradbury Eggleston syndrome, Bradbury-Eggleston syndrome, PAF, Pure dysautonomia, Pure idiopatic dysautonomia, idiopathic orthostatic hypotension, idiopathic orthostatic hypotension (a symptom), orthostatic hypotension (a symptom)
30 clinical trials for this condition and its sub-types, 18 tagged with Pure autonomic failure itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
Hope for rare brain disease: new drug aims to slow MSA
Disease control OngoingThis study tests an experimental drug called Lu AF82422 in 64 people with multiple system atrophy (MSA), a rare and serious brain disease. The goal is to see if the drug can slow down the worsening of symptoms like movement problems and daily living difficulties. Participants rec…
Phase 2 • Sponsor: H. Lundbeck A/S • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
-
New drug aims to stop the dizziness of standing up
Symptom relief OngoingThis study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…
Phase 2 • Sponsor: CuraSen Therapeutics, Inc. • Aim: Symptom relief
Last updated Aug 30, 2026 00:00 UTC