Pulmonary non-tuberculous mycobacterial infection

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This trial tests a new combination of antibiotics (called Arm D) against standard treatments for a rare lung infection caused by Mycobacterium abscessus. About 300 people with or without cystic fibrosis will take part. The goal is to see if the new combo clears the infection bett…

This early study tests a special cocktail of viruses (phages) designed to attack a drug-resistant bacterium causing chronic lung infection. Only one person will receive the treatment alongside their usual antibiotics. The goal is to see if it's safe and can reduce the amount of b…

This study tests whether placing one-way valves in the lungs can shrink cavities caused by drug-resistant tuberculosis (TB) or nontuberculous mycobacteria (NTM) infections. The valves block airflow into the cavity, creating a low-oxygen environment that may slow or stop bacterial…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study looks at a lung infection called NTM lung disease in South China. Researchers will review medical records of about 1,500 patients and collect samples from around 100 current patients to learn how the immune system reacts. The goal is to help doctors diagnose and manage…

This study looks at how the body's immune response and nutrition are linked to the progression of nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will analyze immune cells from the lungs and blood of 50 adults with confirmed or suspe…