Proliferative diabetic retinopathy
MONDO:0001660Advanced retinopathy due to diabetes mellitus characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.
39 clinical trials for this condition and its sub-types, 19 tagged with Proliferative diabetic retinopathy itself.
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Can an eye injection boost laser therapy for diabetic retinopathy?
Disease control CompletedResearchers compare two approaches for proliferative diabetic retinopathy, a condition where abnormal blood vessels grow in the retina and can cause vision loss. One group receives standard pan-retinal laser photocoagulation alone. The other receives the same laser treatment plus…
Sponsor: Aswan University • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Can a common Anti-Inflammatory eye drop slow diabetic vision loss?
Disease control CompletedThis study tests whether ketorolac, an anti-inflammatory eye drop, can reduce inflammation in the eyes of people with diabetic retinopathy and slow the disease. About 164 adults with type 2 diabetes will use either the active drop or a placebo for up to 3 years. Researchers will …
Phase 1 • Sponsor: Stephen J. Kim, MD • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Timing eye injections: could 3, 7, or 14 days before surgery matter?
Disease control CompletedThis trial tests whether giving anti-VEGF injections 3, 7, or 14 days before surgery makes a difference for people with proliferative diabetic retinopathy, a complication of diabetes that causes abnormal blood vessels in the eye. Participants are randomly assigned to one of three…
Sponsor: Jie Li • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Eye injections could clear Diabetes-Related bleeding and save sight
Disease control CompletedThis study tests whether injections of ranibizumab, a drug that blocks abnormal blood vessel growth, can help clear bleeding inside the eye in people with diabetes. The bleeding, called diabetic vitreous hemorrhage, can blur or block vision. Participants receive the injection and…
Phase 4 • Sponsor: Benha University • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Could a daily pill help save sight in diabetic retinopathy?
Disease control CompletedThis study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …
Phase 2 • Sponsor: Ocuphire Pharma, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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New injection may replace laser for diabetic eye disease
Disease control CompletedThis study tested whether an eye injection called brolucizumab works as well as laser treatment for people with proliferative diabetic retinopathy, a serious eye condition caused by diabetes. 689 participants received either the injection or laser, and researchers measured vision…
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Eye injection may ease pain of laser surgery for diabetic patients
Symptom relief CompletedThis study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…
Phase 4 • Sponsor: Asociación para Evitar la Ceguera en México • Aim: Symptom relief
Last updated Jul 16, 2026 00:00 UTC
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Could your genes predict blindness from diabetes?
Knowledge-focused CompletedThis study examined whether certain genes are linked to a severe form of diabetic eye disease called proliferative diabetic retinopathy (PDR). Researchers analyzed DNA from 302 people with type 2 diabetes, some with PDR and some without. The goal was to find genetic markers that …
Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC