Progressive non-fluent aphasia

MONDO:0015059

Progressive non-fluent aphasia (PNFA) is a form of frontotemporal dementia (FTD), characterized by agrammatism, laborious speech, alexia, and agraphia, frequently accompanied by apraxia of speech (AOS). Language comprehension is relatively preserved.

Also known as: Agramatic variant of PPA, Agramatic variant of primary progressive aphasia, Primary Progressive Nonfluent aphasia, non-fluent variant PPA, non-fluent primary progressive aphasia

60 clinical trials for this condition and its sub-types, 24 tagged with Progressive non-fluent aphasia itself.

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Where it sits in the disease tree

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Part of

↑ Movement disorder (805) ↑ GRN-related frontotemporal lobar degeneration with Tdp43 inclusions (47)

Sub-types of Progressive non-fluent aphasia

Semantic dementia 32 trials
1 sub-type
- Frontotemporal dementia, right temporal atrophy variant 0 trials

Including sub-types (60) Tagged with Progressive non-fluent aphasia (24)

Trials to join now! 29 Not yet recruiting 6 Not yet finished but already full! 11 Completed 13 Terminated 1

Can a synthetic cannabinoid calm agitation in frontotemporal dementia?

Symptom relief Stopped early

This phase 2 trial tests whether nabilone, a synthetic cannabinoid, can reduce agitation in people with frontotemporal dementia (FTD). Participants receive both nabilone and a placebo in random order to compare effects. The study includes adults with behavioral variant FTD or pri…

Phase 2 • Sponsor: Simon Ducharme, MD • Aim: Symptom relief

Last updated Jul 30, 2026 00:00 UTC

Progressive non-fluent aphasia

Where it sits in the disease tree

Can a synthetic cannabinoid calm agitation in frontotemporal dementia?