Progressive non-fluent aphasia
MONDO:0015059Progressive non-fluent aphasia (PNFA) is a form of frontotemporal dementia (FTD), characterized by agrammatism, laborious speech, alexia, and agraphia, frequently accompanied by apraxia of speech (AOS). Language comprehension is relatively preserved.
Also known as: Agramatic variant of PPA, Agramatic variant of primary progressive aphasia, Primary Progressive Nonfluent aphasia, non-fluent variant PPA, non-fluent primary progressive aphasia
60 clinical trials for this condition and its sub-types, 24 tagged with Progressive non-fluent aphasia itself.
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Sub-types of Progressive non-fluent aphasia
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Semantic dementia 32 trials
1 sub-type
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Can singing and constraint therapy rebuild speech after stroke?
Disease control Not yet recruitingThis trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…
Sponsor: Universidad de Granada • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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Can ancient chinese music therapy help stroke survivors speak again?
Symptom relief Not yet recruitingThis study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …
Sponsor: Fujian University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC