Progressive familial intrahepatic cholestasis
MONDO:0015762Progressive familial intrahepatic cholestasis (PFIC) refers to a heterogeneous group of autosomal recessive disorders of childhood that disrupt bile formation and present with cholestasis of hepatocellular origin.
Also known as: PFIC, cholestasis, progressive familial intrahepatic
23 clinical trials for this condition and its sub-types, 16 tagged with Progressive familial intrahepatic cholestasis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Progressive familial intrahepatic cholestasis
-
Can a bile acid blocker ease severe itching in a rare liver disease?
Disease control Expanded access (ended)This expanded access program offers the experimental drug odevixibat to people with progressive familial intrahepatic cholestasis (PFIC) who have severe itching and high bile acid levels but cannot join the main clinical trial. The drug works by blocking a bile acid transporter i…
Sponsor: Albireo • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
-
New study analyzes Odevixibat's impact on rare liver disease outcomes
Knowledge-focused OngoingThis study looks at a rare liver disease called PFIC, which causes severe itching and liver damage. Researchers compare patients who took the drug odevixibat to those who did not, using data from past studies and a patient registry. The goal is to see if odevixibat helps avoid li…
Sponsor: Ipsen • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
-
Major study on rare childhood liver diseases halted
Knowledge-focused PausedThis study followed children and young adults with genetic liver diseases that cause bile buildup. The goal was to track how these diseases progress over time, including the need for liver transplants or other complications. No treatments were tested; the aim was simply to learn …
Sponsor: Arbor Research Collaborative for Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC