Progressive familial heart block, type 1A
MONDO:0007240An autosomal dominant inherited cardiac bundle branch disorder which can progress to complete heart block.
Also known as: Lenegre's disease, PFHB1A, SCN5A progressive familial heart block, heart block, progressive, type IA, progressive familial heart block caused by mutation in SCN5A, progressive familial heart block, type IA, Cardiac conduction defect, nonprogressive, Cardiac conduction defect, progressive
53 clinical trials for this condition and its sub-types, 19 tagged with Progressive familial heart block, type 1A itself.
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New pacemaker lead aims to keep Heart's natural rhythm
Disease control Recruiting nowThis study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …
Sponsor: Boston Scientific Corporation • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Heart device showdown: could CCM beat CRT for chagas patients?
Disease control Recruiting nowThis study compares two implantable heart devices—Cardiac Contractility Modulation (CCM) and Cardiac Resynchronization Therapy (CRT)—in people with Chagas heart disease and advanced heart failure. The goal is to see which device better improves quality of life and heart function.…
Sponsor: InCor Heart Institute • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New study aims to cut unnecessary pacemakers after heart valve procedure
Disease control Recruiting nowThis study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…
Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New pacing technique could improve heart function in heart failure patients
Disease control Recruiting nowThis study compares a new type of heart pacing (His-bundle pacing) to standard pacing in 120 adults with heart failure and right bundle-branch block. The goal is to see if the new method better improves the heart's pumping ability over 6 months. Participants will receive one of t…
Sponsor: University of Rochester • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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New pacemaker technique aims to boost heart failure treatment
Disease control Recruiting nowThis study tests whether a newer pacing method called left bundle branch pacing (LBBP) works better than the standard biventricular pacing for people with chronic heart failure and reduced pumping ability. About 60 adults with heart failure and a specific electrical delay in the …
Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences • Aim: Disease control
Last updated Jun 26, 2026 16:17 UTC
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AI breakthrough could spot hidden heart attacks in patients with tricky ECG patterns
Diagnosis Recruiting nowThis study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…
Sponsor: Konya City Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 13:01 UTC
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New pacing technique aims to outperform standard therapy for heart failure
Symptom relief Recruiting nowResearchers are testing whether a pacing technique called left bundle branch area pacing, guided by detailed imaging and electrical data, can improve outcomes for people with heart failure and left bundle branch block. The trial enrolls 100 adults with non-ischemic cardiomyopathy…
Sponsor: Second Affiliated Hospital of Nanchang University • Aim: Symptom relief
Last updated Sep 13, 2026 00:00 UTC
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3D heart mapping may sharpen pacemaker precision
Knowledge-focused Recruiting nowThis study uses 3D mapping to explore the electrical and structural features of a specific area in the heart called the left bundle branch area. The goal is to improve how pacemaker leads are placed in that region. Researchers will review data from 30 patients, ages 18 to 88, who…
Sponsor: Steward St. Elizabeth's Medical Center of Boston, Inc. • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC