Progesterone resistance

Researchers are testing a combination of a gonadotropin-releasing hormone agonist injection and the drug letrozole in obese women with early-stage endometrial cancer that has not responded to progestin. The goal is to see if this hormone-blocking approach can shrink tumors and al…

Researchers test whether a combination of GnRHa and letrozole can shrink early endometrial cancer or atypical hyperplasia in non-obese patients who have not responded to progestin therapy. The trial compares this regimen with Diane-35 plus metformin. About 80 participants receive…

This early-stage trial tests a new vaginal product (Callavid) that delivers 400mg of progesterone to women with luteal phase insufficiency, a condition that can affect fertility. The study compares it to an existing pessary to see if it is safe, well-tolerated, and easy to use. 2…

This pilot study looks at how progesterone levels change after using a hormone shot (hCG) to trigger ovulation in women preparing for frozen embryo transfer. Forty women will give blood samples over six days to track their hormone patterns. The goal is to learn if hCG affects the…