Primary syphilis
MONDO:0002896The subclinical or symptomatic stage of syphilis, occurring at an average of three weeks after contact with an infected individual. It manifests with one or more painless, indurated ulcers (chancres) of the skin or mucous membranes at the site of inoculation. These lesions heal spontaneously within a few weeks.
Also known as: early syphilis, symptomatic
16 clinical trials for this condition and its sub-types, 7 tagged with Primary syphilis itself.
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Could adding a common antibiotic beat syphilis in HIV patients?
Disease control Recruiting nowThis study tests whether adding doxycycline to the standard penicillin shot works better for treating early syphilis in people with HIV. About 688 adults will be randomly assigned to get either penicillin alone or penicillin plus a week of doxycycline pills. The main goal is to s…
Sponsor: National Taiwan University Hospital • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Could a pill replace the shot for syphilis?
Disease control Recruiting nowThis study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…
Phase 3 • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Hidden syphilis: new study targets silent spread in women and straight men
Knowledge-focused Recruiting nowThis study aims to understand how syphilis bacteria spread from people without visible symptoms, focusing on women and men who have sex with women only—groups often overlooked in past research. Researchers will collect swabs and blood samples from 480 participants with early syph…
Sponsor: Monash University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC