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Primary sclerosing cholangitis
MONDO:0013433Primary sclerosing cholangitis (PSC) is a rare, slowly progressive liver disease characterized by inflammation and destruction of the intra- and/or extra-hepatic bile ducts that lead to cholestasis, liver fibrosis, liver cirrhosis and ultimately liver failure.
Also known as: PSC, cholangitis, primary sclerosing
57 clinical trials for this condition and its sub-types, 54 tagged with Primary sclerosing cholangitis itself.
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Sub-types of Primary sclerosing cholangitis
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New drug A3907 tested for rare liver disease, study halted early
Disease control Stopped earlyThis study tested a drug called A3907 in 18 adults with Primary Sclerosing Cholangitis (PSC), a rare liver disease. The goal was to check if the drug is safe and how the body processes it. The study was stopped early, so results are limited.
Phase 2 • Sponsor: Albireo, an Ipsen Company • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Antibiotic vancomycin tested as PSC treatment – trial stopped early
Disease control Stopped earlyThis study tested whether the antibiotic vancomycin, taken by mouth, is safe and effective for adults with primary sclerosing cholangitis (PSC), a rare liver disease. About 102 participants were randomly assigned to receive vancomycin or a placebo. The main goal was to see if van…
Phase 2/3 • Sponsor: Elizabeth Carey • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Blood test may tame the tightrope walk of transplant drugs
Diagnosis Stopped earlyThis study tests whether a blood test called TruGraf can help doctors fine-tune immunosuppression medications in liver transplant recipients with autoimmune liver diseases like autoimmune hepatitis, primary sclerosing cholangitis, or primary biliary cirrhosis. The test measures g…
Sponsor: Washington University School of Medicine • Aim: Diagnosis
Last updated Aug 09, 2026 00:00 UTC