Primary progressive aphasia
MONDO:0019806Primary progressive aphasia (PPA) is a neurodegenerative disorder, characterized by a primary dissolution of language, with relative sparing of other mental faculties for at least the first 2 years of illness. PPA is recognized as the language variant in the frontotemporal dementia (FTD) spectrum of disorders. PPA can be classified into 3 subtypes based on specific speech and language features: semantic dementia (SD), progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (lv-PPA).
Also known as: Mesulam syndrome, PPA, primary progressive aphasia syndrome
71 clinical trials for this condition and its sub-types, 42 tagged with Primary progressive aphasia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Primary progressive aphasia
-
GRN-related frontotemporal lobar degeneration with Tdp43 inclusions 6 trials · 47 incl. sub-types
1 sub-type
- Progressive non-fluent aphasia 23 trials · 44 incl. sub-types Sub-types →
-
Logopenic progressive aphasia 15 trials
Most studied deeper sub-types
-
Can a synthetic cannabinoid calm agitation in frontotemporal dementia?
Symptom relief Stopped earlyThis phase 2 trial tests whether nabilone, a synthetic cannabinoid, can reduce agitation in people with frontotemporal dementia (FTD). Participants receive both nabilone and a placebo in random order to compare effects. The study includes adults with behavioral variant FTD or pri…
Phase 2 • Sponsor: Simon Ducharme, MD • Aim: Symptom relief
Last updated Jul 30, 2026 00:00 UTC
-
Could a Head-Zap at home boost your brain?
Symptom relief Stopped earlyThis study tested whether a gentle, non-invasive brain stimulation technique (tDCS) done at home, along with computer-based brain games, could improve thinking and language skills in people with primary progressive aphasia, mild cognitive impairment, or dementia. Participants use…
Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
-
Brainwave training tested for aphasia recovery
Symptom relief Stopped earlyThis study tested whether EEG neurofeedback—a type of brain training that uses real-time brainwave readings—can help people with aphasia (trouble speaking or understanding language) improve their communication, sleep, and anxiety. Seven adults with aphasia from stroke or primary …
Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC