Primary pigmented nodular adrenocortical disease

MONDO:0015999

A form of bilateral adrenocortical hyperplasia that is often associated with adrenocorticotrophin hormone (ACTH) independent Cushing syndrome and is characterized by small to normal sized adrenal glands containing multiple small cortical pigmented nodules (less than 1 cm in diameter).

Also known as: PPNAD, pigmented nodular adrenocortical disease, pigmented nodular adrenocortical disease, primary, primary pigmented nodular adrenal dysplasia

4 clinical trials for this condition and its sub-types, 2 tagged with Primary pigmented nodular adrenocortical disease itself.

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Where it sits in the disease tree

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↑ Hereditary disease (18235) ↑ Adrenal gland disorder (354)

Sub-types of Primary pigmented nodular adrenocortical disease

Pigmented nodular adrenocortical disease, primary, 1 1 trial
Isolated primary pigmented nodular adrenocortical disease 0 trials
Pigmented nodular adrenocortical disease, primary, 2 0 trials
Pigmented nodular adrenocortical disease, primary, 3 0 trials
Pigmented nodular adrenocortical disease, primary, 4 0 trials

Including sub-types (4) Tagged with Primary pigmented nodular adrenocortical disease (2)

Trials to join now! 1 Not yet recruiting 1 Completed 2

Tiny trial to see if a dye helps adrenal surgery

Knowledge-focused Not yet recruiting

This study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…

Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:32 UTC

Primary pigmented nodular adrenocortical disease

Where it sits in the disease tree

Tiny trial to see if a dye helps adrenal surgery