Primary ovarian failure

This study looks at how hormone replacement therapy (HRT) affects adolescents aged 11-19 with premature ovarian insufficiency (POI), a condition where ovaries stop working before age 40. Participants receive estrogen patches and progesterone pills over 2 years, with regular check…

This study looks at two ways of taking progesterone for teens with Turner syndrome who are on hormone replacement therapy. One group takes progesterone for 12 days each month, the other takes it every day. Researchers will track bleeding patterns and how the teens feel, to see wh…

This trial is testing whether infusions of stem cells from human umbilical cord tissue can safely help women with premature ovarian insufficiency (POI), a condition where the ovaries stop working before age 40, leading to irregular periods and fertility challenges. The study invo…

This study tests whether transplanting a woman's own previously frozen ovarian tissue can restore fertility and normal hormone levels after chemotherapy or radiation caused ovarian failure. Five women who had ovarian tissue frozen before cancer treatment will receive the tissue b…

This trial investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can restart menstrual cycles and improve hormone levels. It includes 100 women under 40 with premature ovarian failure (early menopause). Participants receive either PRP or a place…

This study tests whether a traditional Chinese herbal formula (Bu Shen Yi Qi) combined with the hormone DHEA can improve ovarian function in women with diminished ovarian reserve. 74 women aged 20-40 will receive either the herbal formula plus DHEA or a placebo plus DHEA for 12 w…

This study tests whether using the hormone dydrogesterone (taken as a pill) alongside standard fertility injections can help women with low ovarian reserve collect more eggs for IVF. The trial compares this approach to the usual GnRH antagonist protocol. Researchers will track pr…

This pilot study is testing whether eating fermented poi every day for four weeks can improve the gut health of pregnant women and lower their risk of developing gestational diabetes. Fifty pregnant women between 10 and 24 weeks will eat one pound of poi daily and receive nutriti…

This study is creating and testing a nurse-led program for women who experience early menopause after cancer. The program includes personalized education, decision support, and skills to manage menopause symptoms. About 117 women who have completed cancer treatment will take part…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This observational study will follow 45 women with primary ovarian insufficiency (POI)—a condition that causes early menopause—who are starting estrogen replacement therapy. Researchers will measure heart health markers before and after 6 months of treatment and compare them to h…

This study looks at whether freezing ovarian tissue can help preserve fertility in people aged 2-21 with conditions like Turner syndrome, galactosemia, or premature ovarian insufficiency. Participants may have surgery to remove and freeze a gonad, with a small piece used for rese…

This study surveys women under 40 with lupus who are starting cyclophosphamide, a drug that can damage ovaries and cause infertility. Some received an additional drug called GnRHa to protect their ovaries. Researchers will compare menstrual health and fertility between those who …

This study follows 1080 women diagnosed with premature ovarian insufficiency (POI) before age 40. Researchers will track their health over time, including bone density, hormone levels, and mental well-being. The goal is to identify risk factors and understand how POI affects over…

This study aims to find genes that may cause infertility in people with non-obstructive azoospermia (low or no sperm) or primary ovarian insufficiency (early menopause). Researchers will collect saliva samples from 500 adults to look for genetic differences. No new treatments are…

This study at Strasbourg University Hospital surveys 20 teenage girls (ages 11-18) with female hypogonadism and their parents to assess their knowledge of hormone replacement therapy. The goal is to identify gaps in understanding so that better educational workshops can be design…

This study looks at how early menopause (premature ovarian insufficiency) affects the heart's electrical signals, which can raise the risk of dangerous heart rhythms. Researchers will compare 120 women with and without this condition, and also check how hormone replacement therap…