Primary ovarian failure
MONDO:0005387Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Also known as: primary ovarian failure, female hypergonadotropic hypogonadism, hypergonadotrophic ovarian failure, hypergonadotropic hypogonadism, hypergonadotropic hypogonadism (female), premature menopause, premature ovarian failure, premature ovarian insufficiency
103 clinical trials for this condition and its sub-types, 53 tagged with Primary ovarian failure itself.
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Sub-types of Primary ovarian failure
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Inherited primary ovarian failure 2 trials · 47 incl. sub-types
41 sub-types
- Turner syndrome 28 trials Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Classic galactosemia 3 trials
- Trisomy X 3 trials
- 46 XX gonadal dysgenesis 1 trial Sub-types →
- Congenital lipoid adrenal hyperplasia due to STAR deficency 1 trial Sub-types →
- Premature ovarian failure 1 1 trial Sub-types →
- 46,XX ovarian dysgenesis-short stature syndrome 0 trials
- Perrault syndrome 0 trials Sub-types →
- Satoyoshi syndrome 0 trials
- X small rings 0 trials
- Aromatase deficiency 0 trials
- Blepharophimosis, ptosis, and epicanthus inversus syndrome 0 trials Sub-types →
- Osteosclerosis-ichthyosis-premature ovarian failure syndrome 0 trials
- Premature ovarian failure 10 0 trials
- Premature ovarian failure 11 0 trials
- Premature ovarian failure 12 0 trials
- Premature ovarian failure 13 0 trials
- Premature ovarian failure 14 0 trials
- Premature ovarian failure 15 0 trials
- Premature ovarian failure 16 0 trials
- Premature ovarian failure 17 0 trials
- Premature ovarian failure 18 0 trials
- Premature ovarian failure 19 0 trials
- Premature ovarian failure 20 0 trials
- Premature ovarian failure 21 0 trials
- Premature ovarian failure 22 0 trials
- Premature ovarian failure 23 0 trials
- Premature ovarian failure 24 0 trials
- Premature ovarian failure 25 0 trials
- Premature ovarian failure 26 0 trials
- Premature ovarian failure 2A 0 trials
- Premature ovarian failure 2B 0 trials
- Premature ovarian failure 3 0 trials
- Premature ovarian failure 4 0 trials
- Premature ovarian failure 5 0 trials
- Premature ovarian failure 6 0 trials
- Premature ovarian failure 7 0 trials
- Premature ovarian failure 8 0 trials
- Premature ovarian failure 9 0 trials
- Tetrasomy X 0 trials
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Premature menopause 22 trials
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Acquired primary ovarian failure 1 trial
Most studied deeper sub-types
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Can a blood injection reboot ovaries? small trial tests PRP for fertility
Disease control OngoingThis study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…
Sponsor: ART Fertility Clinics LLC • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Can stem cells restore fertility in early menopause?
Disease control PausedThis study tests whether stem cells from umbilical cords can safely help women with premature ovarian failure (early menopause). Twelve participants receive stem cell infusions, and doctors monitor menstrual cycles, hormone levels, and follicle growth. The goal is to see if this …
Phase 2 • Sponsor: Sclnow Biotechnology Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Stem cell shot into ovaries aims to tame perimenopause symptoms
Disease control By invitation onlyThis study looks at whether injecting special stem-like cells called Muse cells directly into the ovaries can help women aged 28 to 70 who are in perimenopause. The cells may repair tissue, reduce inflammation, and improve hormone balance. Researchers will track safety, hormone l…
Sponsor: Healing Hope International • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Could stem cell exosomes restore fertility? new trial tests hope for early ovarian failure
Disease control OngoingThis early-stage study tests whether exosomes from umbilical cord stem cells can help women with premature ovarian insufficiency (early menopause). The treatment aims to improve ovarian function and quality of life. About 60 women aged 20-39 will receive the experimental therapy,…
Phase 1/2 • Sponsor: International Peace Maternity and Child Health Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Ovarian graft could spare young cancer patients from early menopause
Disease control OngoingThis early-phase trial tests whether moving a piece of a woman's own ovary to the fatty tissue of her inner thigh before pelvic radiation can keep her ovaries working. The study includes 22 women aged 35 or younger with locally advanced cervical cancer. The goal is to see if the …
Phase 1/2 • Sponsor: MARILIA ALBANEZI BERTOLAZZI • Aim: Disease control
Last updated Jun 26, 2026 14:04 UTC
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New study aims to uncover hidden heart risks in women
Knowledge-focused OngoingThis pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…
Sponsor: Ottawa Heart Institute Research Corporation • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Gut bugs linked to early menopause?
Knowledge-focused OngoingThis study looks at gut bacteria in 30 women with premature ovarian failure and 30 healthy women. Researchers compare stool and blood samples to see if differences in gut microbes are tied to hormone levels. The goal is to learn more, not to test a treatment.
Early phase 1 • Sponsor: Songling Zhang • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Can genes predict fertility loss after chemo?
Knowledge-focused OngoingThis study follows 73 young women with breast cancer to see if certain genes make them more likely to lose fertility after chemotherapy. Researchers measure ovarian reserve (egg supply) before and up to 5 years after treatment. The goal is to better predict who might face fertili…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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New study tracks ovarian health after chemo in young women
Knowledge-focused OngoingThis study follows 196 women aged 11-35 who are receiving chemotherapy for cancer. Researchers measure hormone levels and ovarian follicles before, during, and after treatment to see how the ovaries are affected. The goal is to better understand the risk of early menopause and fe…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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New algorithm aims to catch ovarian damage early in young cancer survivors
Knowledge-focused CancelledThis study was designed to see if a new monitoring algorithm could detect early signs of ovarian damage in women and girls who had cancer treatment. Researchers planned to compare a group using the new algorithm with a group that received standard care. However, the study was wit…
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:42 UTC