Primary ovarian failure
MONDO:0005387Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Also known as: primary ovarian failure, female hypergonadotropic hypogonadism, hypergonadotrophic ovarian failure, hypergonadotropic hypogonadism, hypergonadotropic hypogonadism (female), premature menopause, premature ovarian failure, premature ovarian insufficiency
104 clinical trials for this condition and its sub-types, 53 tagged with Primary ovarian failure itself.
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Sub-types of Primary ovarian failure
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Inherited primary ovarian failure 2 trials · 48 incl. sub-types
41 sub-types
- Turner syndrome 29 trials Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Classic galactosemia 3 trials
- Trisomy X 3 trials
- 46 XX gonadal dysgenesis 1 trial Sub-types →
- Congenital lipoid adrenal hyperplasia due to STAR deficency 1 trial Sub-types →
- Premature ovarian failure 1 1 trial Sub-types →
- 46,XX ovarian dysgenesis-short stature syndrome 0 trials
- Perrault syndrome 0 trials Sub-types →
- Satoyoshi syndrome 0 trials
- X small rings 0 trials
- Aromatase deficiency 0 trials
- Blepharophimosis, ptosis, and epicanthus inversus syndrome 0 trials Sub-types →
- Osteosclerosis-ichthyosis-premature ovarian failure syndrome 0 trials
- Premature ovarian failure 10 0 trials
- Premature ovarian failure 11 0 trials
- Premature ovarian failure 12 0 trials
- Premature ovarian failure 13 0 trials
- Premature ovarian failure 14 0 trials
- Premature ovarian failure 15 0 trials
- Premature ovarian failure 16 0 trials
- Premature ovarian failure 17 0 trials
- Premature ovarian failure 18 0 trials
- Premature ovarian failure 19 0 trials
- Premature ovarian failure 20 0 trials
- Premature ovarian failure 21 0 trials
- Premature ovarian failure 22 0 trials
- Premature ovarian failure 23 0 trials
- Premature ovarian failure 24 0 trials
- Premature ovarian failure 25 0 trials
- Premature ovarian failure 26 0 trials
- Premature ovarian failure 2A 0 trials
- Premature ovarian failure 2B 0 trials
- Premature ovarian failure 3 0 trials
- Premature ovarian failure 4 0 trials
- Premature ovarian failure 5 0 trials
- Premature ovarian failure 6 0 trials
- Premature ovarian failure 7 0 trials
- Premature ovarian failure 8 0 trials
- Premature ovarian failure 9 0 trials
- Tetrasomy X 0 trials
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Premature menopause 22 trials
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Acquired primary ovarian failure 1 trial
Most studied deeper sub-types
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Own bone marrow cells aimed at restarting ovaries
Cure CompletedResearchers are testing whether injecting a woman's own bone marrow cells into her ovaries can restore ovarian function in premature ovarian insufficiency, a condition where the ovaries stop working before age 40. Ten women with the diagnosis will receive the treatment, which inv…
Sponsor: abdulmajeed hammadi • Aim: Cure
Last updated Sep 16, 2026 00:00 UTC
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Could a Blood-Stimulating drug revive failing ovaries?
Disease control CompletedThis pilot trial tests whether a drug called G-CSF, given as a short course of injections, can improve markers of ovarian reserve in women aged 25-40 with premature ovarian insufficiency (POI). The main question is whether treatment can lower FSH levels, raise AMH, and increase a…
Phase 2 • Sponsor: Trio Fertility • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Could cell-derived vesicles restart the ovaries? a new trial investigates
Disease control CompletedThis early-phase trial tests whether injecting tiny particles called extracellular vesicles, derived from bone marrow stem cells, directly into the ovary is safe for women with premature ovarian failure. The study includes 10 women aged 20–38 who have had no menstrual period for …
Phase 1/2 • Sponsor: Royan Institute • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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Frozen ovary tissue awakened to restore fertility in women with early menopause
Disease control CompletedThis study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…
Sponsor: The First Affiliated Hospital of Zhengzhou University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Stem cell gene therapy for early menopause: 2.5-Year Follow-Up shows promise
Disease control CompletedThis study followed 86 women under 40 with premature ovarian failure (early menopause) who had received a one-time gene therapy using their own stem cells. The goal was to check long-term safety and see if hormone levels and fertility improved over 2.5 years. No new treatment was…
Sponsor: Ukraine Association of Biobank • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Stem cell shot aims to restore ovarian function in small safety trial
Disease control CompletedThis early-stage study tested whether a single injection of stem cells from donated umbilical cords is safe for women with premature ovarian insufficiency (early menopause). Only 6 women took part, and the main goal was to check for side effects, not to prove it works. Researcher…
Phase 1 • Sponsor: CHABiotech CO., Ltd • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Hormone therapy may boost sex life in early menopause, study hopes
Knowledge-focused CompletedThis study follows 135 women with premature ovarian failure (early menopause) to see if hormone replacement therapy improves their sexual quality of life. Participants fill out questionnaires about sexual function and well-being before starting treatment and again 6 months later.…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Microbiome clues in early ovarian failure: study compares bacteria in women with POI and healthy controls
Knowledge-focused CompletedThis study looked at gut and vaginal bacteria in 20 women with premature ovarian insufficiency (POI) and 20 healthy women of similar age. POI causes ovaries to stop working normally before age 40, affecting hormones and fertility. Researchers collected stool, vaginal swabs, blood…
Sponsor: Westlake University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Stem cell transplant leaves many women with hidden gynecological issues
Knowledge-focused CompletedThis study looked at 51 women who had a stem cell transplant for acute leukemia as adults. Researchers wanted to find out how many had gynecological problems like early menopause, vaginal graft-versus-host disease, or cervical issues two years after transplant. They also checked …
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Menopause timing linked to mental health? new study investigates
Knowledge-focused CompletedThis study looked at 136 women to see if the age they entered menopause is linked to anxiety and depression. Researchers compared women with early menopause (before age 40) to those with natural menopause after 40. Participants filled out standard anxiety questionnaires during a …
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Teen bone health under the microscope: new study looks at why some girls develop weak bones
Knowledge-focused CompletedThis completed study looked back at the medical records of 74 adolescent girls aged 12 to 21 who had bone density scans. Researchers wanted to find out which girls are most at risk for low bone density (osteopenia or osteoporosis), especially those with missed periods or other gy…
Sponsor: Bagcilar Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:13 UTC