Primary orthostatic hypotension
MONDO:0015914Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson's disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication.
Also known as: neurogenic orthostatic hypotension
83 clinical trials for this condition and its sub-types, 12 tagged with Primary orthostatic hypotension itself.
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Browse by category →Sub-types of Primary orthostatic hypotension
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Inherited orthostatic hypotension 0 trials · 71 incl. sub-types
3 sub-types
- Postural orthostatic tachycardia syndrome 71 trials
- Orthostatic hypotension 1 0 trials
- Orthostatic hypotension 2 0 trials
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Could a gentle brain zap help control blood pressure?
Disease control Not yet recruitingThis pilot study tests whether a non-invasive brain stimulation technique called temporal interference can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-treat hypertension, as well as people with low bloo…
Sponsor: Xuanwu Hospital, Beijing • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Smartwatch AI could spot Parkinson's years before symptoms
Knowledge-focused Not yet recruitingThis study tests whether an artificial intelligence model can estimate a person's risk of developing Parkinson's disease. Participants aged 50 and older who have certain early warning signs—like REM sleep behavior disorder, drops in blood pressure upon standing, or reduced sense …
Sponsor: Queen Mary University of London • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC