Primary orthostatic hypotension
MONDO:0015914Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson's disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication.
Also known as: neurogenic orthostatic hypotension
83 clinical trials for this condition and its sub-types, 12 tagged with Primary orthostatic hypotension itself.
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Browse by category →Sub-types of Primary orthostatic hypotension
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Inherited orthostatic hypotension 0 trials · 71 incl. sub-types
3 sub-types
- Postural orthostatic tachycardia syndrome 71 trials
- Orthostatic hypotension 1 0 trials
- Orthostatic hypotension 2 0 trials
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Scientists Fine-Tune diagnostic tools for autonomic nervous system disorders
Knowledge-focused CompletedThis study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Belly band or pill? study tests best way to treat dizzy spells in nerve disease
Knowledge-focused CompletedThis study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…
Early phase 1 • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC