Primary lymphedema
MONDO:0019175A congenital condition that results in swelling in the arms or legs, and can occur during adolescence or adulthood. Loss of motion and pain may also accompany the swelling. Protein-rich lymphatic fluid accumulates in tissues, engorging and enlarging vessels and often causing visible swelling, tenderness, and pain. Left untreated, the affected tissues may continue to swell, and can become hardened or fibrotic and susceptible to infection.
Also known as: Troncular lymphatic malformation, primary lymphedema
66 clinical trials for this condition and its sub-types, 9 tagged with Primary lymphedema itself.
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Sub-types of Primary lymphedema
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Lymphatic malformation 17 trials · 56 incl. sub-types
28 sub-types
- Noonan syndrome 22 trials · 25 incl. sub-types Sub-types →
- Lymphatic malformation 5 8 trials
- Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 4 trials
- Lymphatic malformation 12 2 trials
- MPI-congenital disorder of glycosylation 1 trial
- Deafness-lymphedema-leukemia syndrome 1 trial
- Dahlberg-Borer-Newcomer syndrome 0 trials
- Hennekam syndrome 0 trials Sub-types →
- Norman-Roberts syndrome 0 trials
- Campomelia, Cumming type 0 trials
- Congenital primary lymphedema of Gordon 0 trials
- Hypotrichosis-lymphedema-telangiectasia syndrome 0 trials
- Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 0 trials
- Lymphatic malformation 1 0 trials
- Lymphatic malformation 10 0 trials
- Lymphatic malformation 11 0 trials
- Lymphatic malformation 13 0 trials
- Lymphatic malformation 14 0 trials
- Lymphatic malformation 2 0 trials
- Lymphatic malformation 3 0 trials
- Lymphatic malformation 4 0 trials
- Lymphatic malformation 6 0 trials
- Lymphatic malformation 7 0 trials
- Lymphatic malformation 8 0 trials
- Lymphatic malformation 9 0 trials
- Lymphedema-distichiasis syndrome 0 trials
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Yellow nail syndrome 0 trials
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Chylous ascites 2 trials
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Aagenaes syndrome 1 trial
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German syndrome 1 trial
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2 sub-types
Most studied deeper sub-types
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Cancer drug tested against deadly infant heart disease
Disease control Not yet recruitingResearchers are testing whether trametinib, an FDA-approved cancer drug, can help infants with RASopathies who have a severe, life-threatening heart condition called hypertrophic cardiomyopathy. The trial enrolls about 25 babies with a confirmed genetic diagnosis. Participants re…
Phase 3 • Sponsor: Carelon Research • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Which injection works best for Children's lymphatic malformations? new trial aims to find out
Disease control Not yet recruitingThis study compares two injected drugs, bleomycin and doxycycline, to treat lymphatic malformations (abnormal fluid-filled sacs) in children under 12. About 92 kids will be randomly assigned to one treatment, and doctors will measure how much the malformation shrinks over six mon…
Phase 2 • Sponsor: Basharat Hussain • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New device aims to ease leg swelling in lymphedema patients
Symptom relief Not yet recruitingThis study tests if a new dynamic compression device, used with compression stockings, works as well as current treatments for reducing leg swelling in people with lymphedema. About 98 adults with stage II or III lymphedema will use either the new device or standard wraps and pum…
Sponsor: Jean-Paul Belgrado • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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New compression device could ease lymphedema swelling faster
Symptom relief Not yet recruitingThis study compares a new dynamic compression device to traditional bandages for reducing leg swelling in people with lymphedema. Over 5 days of intensive treatment, 110 participants will wear either the device or standard bandages. The goal is to see which method reduces excess …
Sponsor: Jean-Paul Belgrado • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Beyond swelling: could lymphedema be a Whole-Body biological disorder?
Knowledge-focused Not yet recruitingThis observational study aims to characterize the biological profile of primary and secondary lymphedema by measuring markers of inflammation, blood vessel health, metabolism, lymphatic function, and tissue scarring. It will compare 30 people with primary lymphedema, 30 with seco…
Sponsor: University Medical Centre Ljubljana • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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New study aims to predict bleeding dangers in noonan syndrome patients
Knowledge-focused Not yet recruitingThis study looks at why people with Noonan syndrome often bleed easily, especially from the skin, mouth, or nose. Researchers will compare a simple questionnaire about bleeding history with blood tests in 100 patients. The goal is to find better ways to predict serious bleeding, …
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC